Nature Communications (Nov 2017)

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein

  • Michael B. Battles,
  • Vicente Más,
  • Eduardo Olmedillas,
  • Olga Cano,
  • Mónica Vázquez,
  • Laura Rodríguez,
  • José A. Melero,
  • Jason S. McLellan

DOI
https://doi.org/10.1038/s41467-017-01708-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.