Nature Communications (Nov 2017)
Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein
Abstract
An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.