Association between Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Components of Metabolic Syndrome in Young Chinese Men

Abstract

"nBackground: To investigate the prevalence of metabolic syndrome (MetS) in young Chinese population and assess the as­sociation between HOMA-IR and different components of MetS in young Chinese men."nMethods: Overall 5576 young Chinese subjects (age range [19-44 yr], 3636 men) were enrolled in, who visited our Health Care Center for a related health checkup from March to December 2008. The international diabetes federation (IDF) definition for MetS was used. The SPSS statistical package, version 11.5 was used for the statistical analysis."nResults: The prevalence of MetS was 21.81% in young men and 5.62% in young women. According to suffering from dif­ferent numbers of MetS components, the male subjects were divided into four groups. Numbers of MetS components were more and HOMA-IR values were significantly higher. In this male population, the quartile of HOMA-IR was higher, values of triglyceride (TG), fasting plasma glucose (FBG), systolic blood pressure(SBP), diastolic blood pres­sure(DBP) and waist circumference (WC) were all significantly higher, as well as high density lipoprotein cholesterol (HDL-C) value was significantly lower (P= 0.000). In Spearman's correlation analysis, HOMA-IR was positively corre­lated with TG, FBG, SBP, DBP and WC, and negatively correlated with HDL-C (r= 0.460, 0.464, 0.362, 0.346, 0.586, -0.357, respectively, all P value= 0.000)."nConclusion: The prevalence of MetS in these young Chinese men was obviously high. Insulin resistance played an impor­tant role in occurrence and development of MetS. Waist circumference was the best correlation with HOMA-IR among all components of MetS.

Keywords

• Homeostasis model assessment
• Insulin resistance
• Metabolic syndrome
• Young men