Human Uterine Biopsy: Research Value and Common Pitfalls

Alison Maclean; Areege Kamal; Meera Adishesh; Rafah Alnafakh; Nicola Tempest; Dharani K. Hapangama

doi:10.1155/2020/9275360

International Journal of Reproductive Medicine (Jan 2020)

Human Uterine Biopsy: Research Value and Common Pitfalls

Alison Maclean,
Areege Kamal,
Meera Adishesh,
Rafah Alnafakh,
Nicola Tempest,
Dharani K. Hapangama

Affiliations

Alison Maclean: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK
Areege Kamal: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK
Meera Adishesh: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK
Rafah Alnafakh: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK
Nicola Tempest: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK
Dharani K. Hapangama: Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Member of the Liverpool Health Partnership, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UK

DOI: https://doi.org/10.1155/2020/9275360
Journal volume & issue: Vol. 2020

Abstract

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The human uterus consists of the inner endometrium, the myometrium, and the outer serosa. Knowledge of the function of the uterus in health and disease is relevant to reproduction, fertility, embryology, gynaecology, endocrinology, and oncology. Research performed on uterine biopsies is essential to further the current understanding of human uterine biology. This brief review explores the value of the uterine biopsy in gynaecological and human fertility research and explores the common problems encountered when analysing data generated from different types of uterine biopsies, with the aim of improving the quality, reproducibility, and clinical translatability of future research.

Published in International Journal of Reproductive Medicine

ISSN: 2356-7104 (Print); 2314-5757 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://www.hindawi.com/journals/ijrmed/

About the journal