Nature Communications (Nov 2016)
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
- Charis E. Teh,
- Najoua Lalaoui,
- Reema Jain,
- Antonia N. Policheni,
- Melanie Heinlein,
- Silvia Alvarez-Diaz,
- Julie M. Sheridan,
- Eva Rieser,
- Stefanie Deuser,
- Maurice Darding,
- Hui-Fern Koay,
- Yifang Hu,
- Fiona Kupresanin,
- Lorraine A. O’Reilly,
- Dale I. Godfrey,
- Gordon K. Smyth,
- Philippe Bouillet,
- Andreas Strasser,
- Henning Walczak,
- John Silke,
- Daniel H. D. Gray
Affiliations
- Charis E. Teh
- The Walter and Eliza Hall Institute of Medical Research
- Najoua Lalaoui
- The Walter and Eliza Hall Institute of Medical Research
- Reema Jain
- The Walter and Eliza Hall Institute of Medical Research
- Antonia N. Policheni
- The Walter and Eliza Hall Institute of Medical Research
- Melanie Heinlein
- The Walter and Eliza Hall Institute of Medical Research
- Silvia Alvarez-Diaz
- The Walter and Eliza Hall Institute of Medical Research
- Julie M. Sheridan
- The Walter and Eliza Hall Institute of Medical Research
- Eva Rieser
- Centre for Cell Death, Cancer and Inflammation, University College London
- Stefanie Deuser
- Centre for Cell Death, Cancer and Inflammation, University College London
- Maurice Darding
- Centre for Cell Death, Cancer and Inflammation, University College London
- Hui-Fern Koay
- The Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Yifang Hu
- The Walter and Eliza Hall Institute of Medical Research
- Fiona Kupresanin
- The Walter and Eliza Hall Institute of Medical Research
- Lorraine A. O’Reilly
- The Walter and Eliza Hall Institute of Medical Research
- Dale I. Godfrey
- The Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Gordon K. Smyth
- The Walter and Eliza Hall Institute of Medical Research
- Philippe Bouillet
- The Walter and Eliza Hall Institute of Medical Research
- Andreas Strasser
- The Walter and Eliza Hall Institute of Medical Research
- Henning Walczak
- Centre for Cell Death, Cancer and Inflammation, University College London
- John Silke
- The Walter and Eliza Hall Institute of Medical Research
- Daniel H. D. Gray
- The Walter and Eliza Hall Institute of Medical Research
- DOI
- https://doi.org/10.1038/ncomms13353
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
