Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Dec 2019)
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
- Eric E. Smith,
- Geert Jan Biessels,
- François De Guio,
- Frank Erik deLeeuw,
- Simon Duchesne,
- Marco Düring,
- Richard Frayne,
- M. Arfan Ikram,
- Eric Jouvent,
- Bradley J. MacIntosh,
- Michael J. Thrippleton,
- Meike W. Vernooij,
- Hieab Adams,
- Walter H. Backes,
- Lucia Ballerini,
- Sandra E. Black,
- Christopher Chen,
- Rod Corriveau,
- Charles DeCarli,
- Steven M. Greenberg,
- M. Edip Gurol,
- Michael Ingrisch,
- Dominic Job,
- Bonnie Y.K. Lam,
- Lenore J. Launer,
- Jennifer Linn,
- Cheryl R. McCreary,
- Vincent C.T. Mok,
- Leonardo Pantoni,
- G. Bruce Pike,
- Joel Ramirez,
- Yael D. Reijmer,
- Jose Rafael Romero,
- Stefan Ropele,
- Natalia S. Rost,
- Perminder S. Sachdev,
- Christopher J.M. Scott,
- Sudha Seshadri,
- Mukul Sharma,
- Steven Sourbron,
- Rebecca M.E. Steketee,
- Richard H. Swartz,
- Robert vanOostenbrugge,
- Matthias vanOsch,
- Sanneke vanRooden,
- Anand Viswanathan,
- David Werring,
- Martin Dichgans,
- Joanna M. Wardlaw
Affiliations
- Eric E. Smith
- Department of Clinical NeurosciencesUniversity of CalgaryCalgaryAlbertaCanada
- Geert Jan Biessels
- Department of NeurologyBrain Center Rudolf Magnus, University Medical Center UtrechtUtrechtNetherlands
- François De Guio
- Department of NeurologyLariboisière Hospital, University Paris DiderotParisFrance
- Frank Erik deLeeuw
- Department of NeurologyDonders Institute for BrainCognition and BehaviourDonders Center for Medical Neuroscience, Radboud University Medical CenterNijmegenNetherlands
- Simon Duchesne
- CERVO Research Center, Quebec Mental Health InstituteQuébecCanada
- Marco Düring
- Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig‐Maximilians‐Universität LMUMunichGermany
- Richard Frayne
- Department of Clinical NeurosciencesUniversity of CalgaryCalgaryAlbertaCanada
- M. Arfan Ikram
- Department of EpidemiologyErasmus University Medical CenterRotterdamNetherlands
- Eric Jouvent
- Department of NeurologyLariboisière Hospital, University Paris DiderotParisFrance
- Bradley J. MacIntosh
- Heart and Stroke Foundation Canadian Partnership for Stroke RecoveryDepartment of Medical BiophysicsSunnybrook Research Institute, University of TorontoOntarioCanada
- Michael J. Thrippleton
- Centre for Clinical Brain Sciences, University of EdinburghEdinburghUK
- Meike W. Vernooij
- Department of EpidemiologyErasmus University Medical CenterRotterdamNetherlands
- Hieab Adams
- Department of EpidemiologyErasmus University Medical CenterRotterdamNetherlands
- Walter H. Backes
- Department of Radiology & Nuclear MedicineSchool for Mental Health & Neuroscience, Maastricht University Medical CenterMaastrichtThe Netherlands
- Lucia Ballerini
- Centre for Clinical Brain Sciences, University of EdinburghEdinburghUK
- Sandra E. Black
- Hurvitz Brain Sciences Research ProgramSunnybrook Research Institute, University of TorontoTorontoOntarioCanada
- Christopher Chen
- Memory Aging and Cognition CentreDepartment of PharmacologyNational University of SingaporeSingapore
- Rod Corriveau
- National Institute of Neurological Disorders and StrokeBethesdaMDUSA
- Charles DeCarli
- Department of Neurology and Center for NeuroscienceUniversity of California at DavisDavisCAUSA
- Steven M. Greenberg
- J. Philip Kistler Stroke Research CenterStroke Service and Memory Disorders UnitMassachusetts General HospitalBostonMAUSA
- M. Edip Gurol
- J. Philip Kistler Stroke Research CenterStroke Service and Memory Disorders UnitMassachusetts General HospitalBostonMAUSA
- Michael Ingrisch
- Department of RadiologyLudwig‐Maximilians‐University Hospital MunichMunichGermany
- Dominic Job
- Centre for Clinical Brain Sciences, University of EdinburghEdinburghUK
- Bonnie Y.K. Lam
- Therese Pei Fong Chow Research Centre for Prevention of DementiaGerald Choa Neuroscience CentreLui Che Woo Institute of Innovative MedicineDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongHong Kong
- Lenore J. Launer
- National Institute on Aging, National Institutes of HealthBethesdaMDUSA
- Jennifer Linn
- Institute of Neuroradiology, University Hospital Carl Gustav CarusDresdenGermany
- Cheryl R. McCreary
- Department of Clinical NeurosciencesUniversity of CalgaryCalgaryAlbertaCanada
- Vincent C.T. Mok
- Therese Pei Fong Chow Research Centre for Prevention of DementiaGerald Choa Neuroscience CentreLui Che Woo Institute of Innovative MedicineDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongHong Kong
- Leonardo Pantoni
- Luigi Sacco Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly
- G. Bruce Pike
- Department of Clinical NeurosciencesUniversity of CalgaryCalgaryAlbertaCanada
- Joel Ramirez
- Heart and Stroke Foundation Canadian Partnership for Stroke RecoveryDepartment of Medical BiophysicsSunnybrook Research Institute, University of TorontoOntarioCanada
- Yael D. Reijmer
- Department of NeurologyBrain Center Rudolf Magnus, University Medical Center UtrechtUtrechtNetherlands
- Jose Rafael Romero
- Department of NeurologyBoston University School of MedicineBostonMAUSA
- Stefan Ropele
- Department of NeurologyMedical University of GrazGrazAustria
- Natalia S. Rost
- J. Philip Kistler Stroke Research Center, Massachusetts General HospitalBostonMAUSA
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, University of New South WalesSydneyAustralia
- Christopher J.M. Scott
- Heart and Stroke Foundation Canadian Partnership for Stroke RecoveryDepartment of Medical BiophysicsSunnybrook Research Institute, University of TorontoOntarioCanada
- Sudha Seshadri
- Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences CenterSan AntonioTXUSA
- Mukul Sharma
- Population Health Research InstituteHamiltonOntarioCanada
- Steven Sourbron
- Imaging Biomarkers GroupDepartment of Biomedical Imaging SciencesUniversity of LeedsLeedsUK
- Rebecca M.E. Steketee
- Department of Radiology and Nuclear MedicineErasmus University Medical CenterRotterdamThe Netherlands
- Richard H. Swartz
- Department of Medicine (Neurology)University of TorontoTorontoCanada
- Robert vanOostenbrugge
- Department of NeurologySchool for Mental Health and Neuroscience, Maastricht University Medical CenterMaastrichtthe Netherlands
- Matthias vanOsch
- C.J. Gorter Center for high field MRIDepartment of RadiologyLeiden University Medical CenterLeidenThe Netherlands
- Sanneke vanRooden
- Department of RadiologyLeiden University Medical CenterLeidenThe Netherlands
- Anand Viswanathan
- J. Philip Kistler Stroke Research CenterStroke Service and Memory Disorders UnitMassachusetts General HospitalBostonMAUSA
- David Werring
- University College London Queen Square institute of NeurologyLondonUK
- Martin Dichgans
- Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig‐Maximilians‐Universität LMUMunichGermany
- Joanna M. Wardlaw
- Centre for Clinical Brain Sciences, University of EdinburghEdinburghUK
- DOI
- https://doi.org/10.1016/j.dadm.2019.01.002
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 191 – 204
Abstract
Abstract Introduction Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods Surveys, teleconferences, and an in‐person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness‐neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
Keywords
