PLoS Neglected Tropical Diseases (Nov 2021)

Immunogenicity and safety of primary fractional-dose yellow fever vaccine in autoimmune rheumatic diseases.

  • Adriana Coracini Tonacio,
  • Tatiana do Nascimento Pedrosa,
  • Eduardo Ferreira Borba,
  • Nadia Emi Aikawa,
  • Sandra Gofinet Pasoto,
  • Júlio Cesar Rente Ferreira Filho,
  • Marília Mantovani Sampaio Barros,
  • Elaine Pires Leon,
  • Suzete Cleusa Ferreira Spina Lombardi,
  • Alfredo Mendrone Junior,
  • Adriana de Souza Azevedo,
  • Waleska Dias Schwarcz,
  • Ricardo Fuller,
  • Emily Figueiredo Neves Yuki,
  • Michelle Remião Ugolini Lopes,
  • Rosa Maria Rodrigues Pereira,
  • Percival Degrava Sampaio Barros,
  • Danieli Castro Oliveira de Andrade,
  • Ana Cristina de Medeiros-Ribeiro,
  • Julio Cesar Bertacini de Moraes,
  • Samuel Katsuyuki Shinjo,
  • Renata Miossi,
  • Alberto José da Silva Duarte,
  • Marta Heloisa Lopes,
  • Esper Georges Kallás,
  • Clovis Artur Almeida da Silva,
  • Eloisa Bonfá

DOI
https://doi.org/10.1371/journal.pntd.0010002
Journal volume & issue
Vol. 15, no. 11
p. e0010002

Abstract

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BackgroundBrazil faced a yellow fever(YF) outbreak in 2016-2018 and vaccination was considered for autoimmune rheumatic disease patients(ARD) with low immunosuppression due to YF high mortality.ObjectiveThis study aimed to evaluate, prospectively for the first time, the short-term immunogenicity of the fractional YF vaccine(YFV) immunization in ARD patients with low immunossupression.Methods and resultsA total of 318 participants(159 ARD and 159 age- and sex-matched healthy controls) were vaccinated with the fractional-dose(one fifth) of 17DD-YFV. All subjects were evaluated at entry(D0), D5, D10, and D30 post-vaccination for clinical/laboratory and disease activity parameters for ARD patients. Post-vaccination seroconversion rate(83.7%vs.96.6%, p = 0.0006) and geometric mean titers(GMT) of neutralizing antibodies[1143.7 (95%CI 1012.3-1292.2) vs.731 (95%CI 593.6-900.2), p0.05).ConclusionFractional-dose 17DD-YF vaccine in ARD patients resulted in a high rate of seroconversion rate(>80%) but lower than controls, with a longer but less intense viremia. This vaccine was immunogenic, safe and did not induce flares in ARD under low immunosuppression and may be indicated in YF outbreak situations and for patients who live or travel to endemic areas.Trial registrationThis clinical trial was registered with Clinicaltrials.gov (#NCT03430388).