Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response

Whitney N. Wood; Kyle Mohler; Jesse Rinehart; Michael Ibba

doi:10.1128/mBio.01132-21

mBio (Jun 2021)

Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response

Whitney N. Wood,
Kyle Mohler,
Jesse Rinehart,
Michael Ibba

Affiliations

Whitney N. Wood: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Kyle Mohler: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA
Jesse Rinehart: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA
Michael Ibba: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

DOI: https://doi.org/10.1128/mBio.01132-21
Journal volume & issue: Vol. 12, no. 3

Abstract

Read online

Bacterial antibiotic persistence is a transient physiological state wherein cells become dormant and thereby evade being killed by antibiotics. Once the antibiotic is removed, bacterial persisters are able to resuscitate and repopulate.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal