Journal of Medicinal Plants (Nov 2011)
Evaluating the Anti-leech Activity of Methanolic Extract of Matricaria chamomilla L at Compared with Ivermectin, Mebendasole, Praziquantel, Rafoxanide, Febantel and Albendasole
Abstract
Background: More than 650 types of leech have been recognized in the world that 50 types of these nutrition of blood mammals. So far in the different Nations Pharmacopeia not registered drug for treatment of complications with leech in the world .Chamomile is one of the most widely used and well-documented medicinal plants in the world which used for treatment of anti -spasmodic ,anti-inflammatory and alleviated pain. Objective: This experimental study prepared methanolic extract of Matricaria chamomilla L and selected several chemical drugs such as Febantel, Mebendazole, Rafoxanide, Praziquantel and Ivermectin and studied comparison effects on leech species of limnatis. nilotica. Methods: In this experimental study, 80 number leech species of limnatis nilotica were collected and transfered in glass container which contains 600 ml of spring water placed a number of leech and were accurately recorded paralysis and death from time adding the drugs for 720 minutes. Results: The results showed that the Mebendazole, Praziquantel and Rafoxanid could not dead the leech but Febantel with dose of 100 mg with mean time of 440.44 minutes was killed the leeches. Ivermectine had the best effect on leech and methanolic extract of Matricaria chamomilla L (600b mg/ml) could kill the leaches in the average time of 232.22 min (1+) which recommended use in cases of contamination with leech species limnatis nilotica. Results of this study showed that Ivermectine, Albendasole and methanolic extract of Matricaria chamomilla L recommended use in cases of contamination with leech species limnatis nilotica while lack of effect on leech drugs such as Mebendazole, Praziquantel, Rafoxanid and Febantel because of low effect not recommended.
