COVID-19 and sickle cell disease in Bahrain

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is caused by a newly identified strain of the coronavirus family that has been shown to affect the hemoglobin beta chain, the same chain that has sickle cell disease (SCD) mutation. This study was undertaken to see if COVID-19 infection increased disease severity in patients with SCD. Methods: Mass screening of the Bahraini population was undertaken between February and April 2020. Results: A total of 38,092 Bahraini people were tested for COVID-19 during this period; 378 (1%) were SCD patients. Six patients with SCD had COVID-19 (1.6%): three remained asymptomatic, two had mild symptoms and one required oxygen therapy. The SCD patients had a similar average length of stay when compared with non-SCD COVID-19 patients (10.7 days). Conclusion: The infection rate, clinical course and viral clearance seen for the SCD patients with COVID-19 were no different to those without SCD.

Keywords

• COVID-19
• SARS-CoV-2
• Sickle cell disease