The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Wenyan Wan; Hui Dong; De-Hua Lai; Jiong Yang; Kai He; Xiaoyan Tang; Qun Liu; Geoff Hide; Xing-Quan Zhu; L. David Sibley; Zhao-Rong Lun; Shaojun Long

doi:10.1038/s41467-023-36571-4

Nature Communications (Feb 2023)

The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Wenyan Wan,
Hui Dong,
De-Hua Lai,
Jiong Yang,
Kai He,
Xiaoyan Tang,
Qun Liu,
Geoff Hide,
Xing-Quan Zhu,
L. David Sibley,
Zhao-Rong Lun,
Shaojun Long

Affiliations

Wenyan Wan: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University
Hui Dong: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University
De-Hua Lai: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
Jiong Yang: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
Kai He: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University
Xiaoyan Tang: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University
Qun Liu: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University
Geoff Hide: Biomedical Research and Innovation Centre and Environmental Research and Innovation Centre, School of Science, Engineering and Environment, University of Salford
Xing-Quan Zhu: College of Veterinary Medicine, Shanxi Agricultural University
L. David Sibley: Department of Molecular Microbiology, Washington University School of Medicine in Saint Louis
Zhao-Rong Lun: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
Shaojun Long: National Key Laboratory of Veterinary Public Health Security and School of Veterinary Medicine, China Agricultural University

DOI: https://doi.org/10.1038/s41467-023-36571-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 21

Abstract

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Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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