Three-Component Reactions of 3-Arylidene-3<i>H</i>-Indolium Salts, Isocyanides and Amines

Abstract

A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives.

Keywords

• multicomponent reactions
• isocyanides
• carbenium ions
• indoles
• imidamides
• imidazolones