Three-Component Reactions of 3-Arylidene-3<i>H</i>-Indolium Salts, Isocyanides and Amines
Hung M. Nguyen,
Nikita E. Golantsov,
Alexandra S. Golubenkova,
Victor B. Rybakov,
Leonid G. Voskressensky
Affiliations
Hung M. Nguyen
Department of Organic Chemistry, Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Nikita E. Golantsov
Department of Organic Chemistry, Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Alexandra S. Golubenkova
Department of Organic Chemistry, Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Victor B. Rybakov
Faculty of Chemistry, Lomonosov Moscow State University, 1-3 Leninskiye Gory, 119991 Moscow, Russia
Leonid G. Voskressensky
Department of Organic Chemistry, Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives.
