Nature Communications (Jan 2019)
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
- Luke Whitesell,
- Nicole Robbins,
- David S. Huang,
- Catherine A. McLellan,
- Tanvi Shekhar-Guturja,
- Emmanuelle V. LeBlanc,
- Catherine S. Nation,
- Raymond Hui,
- Ashley Hutchinson,
- Cathy Collins,
- Sharanya Chatterjee,
- Richard Trilles,
- Jinglin L. Xie,
- Damian J. Krysan,
- Susan Lindquist,
- John A. Porco,
- Utpal Tatu,
- Lauren E. Brown,
- Juan Pizarro,
- Leah E. Cowen
Affiliations
- Luke Whitesell
- Department of Molecular Genetics, University of Toronto
- Nicole Robbins
- Department of Molecular Genetics, University of Toronto
- David S. Huang
- Department of Chemistry, Center for Molecular Discovery, Boston University
- Catherine A. McLellan
- Whitehead Institute for Biomedical Research
- Tanvi Shekhar-Guturja
- Department of Molecular Genetics, University of Toronto
- Emmanuelle V. LeBlanc
- Department of Molecular Genetics, University of Toronto
- Catherine S. Nation
- Department of Tropical Medicine, School of Public Health and Tropical Medicine and Vector-Borne Infectious Disease Research Center, Tulane University
- Raymond Hui
- Structural Genomics Consortium, University of Toronto
- Ashley Hutchinson
- Structural Genomics Consortium, University of Toronto
- Cathy Collins
- Department of Molecular Genetics, University of Toronto
- Sharanya Chatterjee
- Department of Biochemistry, Indian Institute of Science
- Richard Trilles
- Department of Chemistry, Center for Molecular Discovery, Boston University
- Jinglin L. Xie
- Department of Molecular Genetics, University of Toronto
- Damian J. Krysan
- Departments of Pediatrics and Microbiology/Immunology, Carver College of Medicine, University of Iowa
- Susan Lindquist
- Whitehead Institute for Biomedical Research
- John A. Porco
- Department of Chemistry, Center for Molecular Discovery, Boston University
- Utpal Tatu
- Department of Biochemistry, Indian Institute of Science
- Lauren E. Brown
- Department of Chemistry, Center for Molecular Discovery, Boston University
- Juan Pizarro
- Department of Tropical Medicine, School of Public Health and Tropical Medicine and Vector-Borne Infectious Disease Research Center, Tulane University
- Leah E. Cowen
- Department of Molecular Genetics, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-018-08248-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both biochemically and in cells.
