Cancers (Aug 2018)
Stereotactic Body Radiation Therapy for Patients with Pulmonary Interstitial Change: High Incidence of Fatal Radiation Pneumonitis in a Retrospective Multi-Institutional Study
- Hiroshi Onishi,
- Hideomi Yamashita,
- Yoshiyuki Shioyama,
- Yasuo Matsumoto,
- Kenji Takayama,
- Yukinori Matsuo,
- Akifumi Miyakawa,
- Haruo Matsushita,
- Masahiko Aoki,
- Keiji Nihei,
- Tomoki Kimura,
- Hiromichi Ishiyama,
- Naoya Murakami,
- Kensei Nakata,
- Atsuya Takeda,
- Takashi Uno,
- Takuma Nomiya,
- Tuyoshi Takanaka,
- Yuji Seo,
- Takafumi Komiyama,
- Kan Marino,
- Shinichi Aoki,
- Ryo Saito,
- Masayuki Araya,
- Yoshiyasu Maehata,
- Licht Tominaga,
- Kengo Kuriyama
Affiliations
- Hiroshi Onishi
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Hideomi Yamashita
- Department of Radiology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 1138655, Japan
- Yoshiyuki Shioyama
- Ion Beam Therapy Center, SAGA-HIMAT Foundation, 3049 Harukoga-machi, Tosu-shi, Saga 8410071, Japan
- Yasuo Matsumoto
- Department of Radiation Oncology, Niigata Cancer Center Hospital, 2-15-3 Kawagishi, Chuo-ku, Niigata 9518566, Japan
- Kenji Takayama
- Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 6068507, Japan
- Yukinori Matsuo
- Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 6068507, Japan
- Akifumi Miyakawa
- Department of Radiology, School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 4678601, Japan
- Haruo Matsushita
- Department of Radiation Oncology, School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 9808574, Japan
- Masahiko Aoki
- Department of Radiology and Radiation Oncology, Hirosaki University School of Medicine, 5 Zaifu-cho Hirosaki city, Aomori 0368562, Japan
- Keiji Nihei
- Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 1138677, Japan
- Tomoki Kimura
- Department of Radiation Oncology, Hiroshima University Hospital, 1-2-3, Kasumi Minami-ku, Hiroshima 7348551, Japan
- Hiromichi Ishiyama
- Department of Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 2520375, Japan
- Naoya Murakami
- Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 1040045, Japan
- Kensei Nakata
- Department of Radiation Oncology, Sapporo Medical University, 16-291 Minami-1jyo-nishi, Chuo-ku, Sapporo-shi, Hokkaido 0608543, Japan
- Atsuya Takeda
- Radiation Oncology Center, Ofuna Chuo Hospital, 6-2-24 Ofuna, Kamakura, Kanagawa 2470056, Japan
- Takashi Uno
- Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 2608670, Japan
- Takuma Nomiya
- Department of Radiation Oncology, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 9909585, Japan
- Tuyoshi Takanaka
- Department of Radiation Oncology, Kanazawa University, 13-1 Takaramachi, Kanazawa 9208641, Japan
- Yuji Seo
- Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 (D10) Yamada-oka, Suita, Osaka 5650871, Japan
- Takafumi Komiyama
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Kan Marino
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Shinichi Aoki
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Ryo Saito
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Masayuki Araya
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Yoshiyasu Maehata
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Licht Tominaga
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- Kengo Kuriyama
- Department of Radiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan
- DOI
- https://doi.org/10.3390/cancers10080257
- Journal volume & issue
-
Vol. 10,
no. 8
p. 257
Abstract
Pretreatment pulmonary interstitial change (PIC) has been indicated as a risk factor of severe radiation pneumonitis (RP) following stereotactic body radiation therapy (SBRT) for early-stage lung cancer, but details of its true effect remain unclear. This study aims to evaluate treatment outcomes of SBRT for stage I non-small cell lung cancer in patients with PIC. A total of 242 patients are included in this study (88% male). The median age is 77 years (range, 55–92 years). A total dose of 40–70 Gy is administered in 4 to 10 fractions during a 4-to-25 day period. One, two, and three-year overall survival (OS) rates are 82.1%, 57.1%, and 42.6%, respectively. Fatal RP is identified in 6.9% of all patients. The percent vital capacity <70%, mean percentage normal lung volume receiving more than 20 Gy (>10%), performance status of 2–4, presence of squamous cell carcinoma, clinical T2 stage, regular use of steroid before SBRT, and percentage predicting forced expiratory volume in one second (<70%) are associated with worse prognoses for OS. Our results indicate that fatal RP frequently occurs after SBRT for stage I lung cancer in patients with PIC.
Keywords