Emerging Infectious Diseases (Nov 2017)

Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru

  • Ruvandhi R. Nathavitharana,
  • Cynthia X. Shi,
  • Leonid Chindelevitch,
  • Roger Calderon,
  • Zibiao Zhang,
  • Jerome T. Galea,
  • Carmen Contreras,
  • Rosa Yataco,
  • Leonid Lecca,
  • Mercedes C. Becerra,
  • Megan B. Murray,
  • Ted Cohen

DOI
https://doi.org/10.3201/eid2311.170077
Journal volume & issue
Vol. 23, no. 11
pp. 1887 – 1890

Abstract

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Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru. The 161 patients with polyclonal infection were more likely than the 115 with clonal or the 2,822 with simple infections to have multidrug-resistant TB.

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