Focal Reactive Overgrowths: Case Series with Review of Literature

Abstract

Focal Reactive Overgrowths (FROGs) are commonly occurring mucosal lesions in oral cavity. FROGs include Focal Fibrous Hyperplasia (FFH), Pyogenic Granuloma (PG), Peripheral Ossifying Fibroma (POF) and Peripheral Giant Cell Granuloma (PGCG). These overgrowths comprise of lesions that are essentially a response to a low-grade stimulus. These lesions have similar clinical and biological behaviour but differ in their histogenesis and histopathological features. Despite the differences, the treatment of all the lesions is essentially the same i.e., efficient plaque control, removal of aetiological factors and conservative excision of the tissue. Though, recurrence rate of these lesions is low, follow up is imperative. Few peripheral odontogenic tumours, benign and malignant epithelial and connective tissue tumours may imitate FROGs clinically. Hence, it is necessary that clinicians have adequate knowledge about FROGs so as to differentiate them from other lesions. Herein, we present a series of eight cases of FROGs, highlighting their clinicopathological features along with a brief review of literature. The aim of this paper is to further the knowledge of FROGs amongst the clinicians.

Keywords

• differential diagnosis
• focal fibrous hyperplasia
• peripheral ossifying fibroma
• peripheral giant cell granuloma
• pyogenic granuloma