Nature Communications (Jun 2022)
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level
- Fei Wang,
- Peiwen Ding,
- Xue Liang,
- Xiangning Ding,
- Camilla Blunk Brandt,
- Evelina Sjöstedt,
- Jiacheng Zhu,
- Saga Bolund,
- Lijing Zhang,
- Laura P. M. H. de Rooij,
- Lihua Luo,
- Yanan Wei,
- Wandong Zhao,
- Zhiyuan Lv,
- János Haskó,
- Runchu Li,
- Qiuyu Qin,
- Yi Jia,
- Wendi Wu,
- Yuting Yuan,
- Mingyi Pu,
- Haoyu Wang,
- Aiping Wu,
- Lin Xie,
- Ping Liu,
- Fang Chen,
- Jacqueline Herold,
- Joanna Kalucka,
- Max Karlsson,
- Xiuqing Zhang,
- Rikke Bek Helmig,
- Linn Fagerberg,
- Cecilia Lindskog,
- Fredrik Pontén,
- Mathias Uhlen,
- Lars Bolund,
- Niels Jessen,
- Hui Jiang,
- Xun Xu,
- Huanming Yang,
- Peter Carmeliet,
- Jan Mulder,
- Dongsheng Chen,
- Lin Lin,
- Yonglun Luo
Affiliations
- Fei Wang
- Lars Bolund Institute of Regenerative Medicine, Qingdao-Europe Advanced Institute for Life Sciences, BGI-Qingdao, BGI-Shenzhen
- Peiwen Ding
- BGI-Shenzhen
- Xue Liang
- Lars Bolund Institute of Regenerative Medicine, Qingdao-Europe Advanced Institute for Life Sciences, BGI-Qingdao, BGI-Shenzhen
- Xiangning Ding
- BGI-Shenzhen
- Camilla Blunk Brandt
- Department of Biomedicine, Aarhus University
- Evelina Sjöstedt
- Department of Neuroscience, Karolinska Institutet
- Jiacheng Zhu
- BGI-Shenzhen
- Saga Bolund
- Department of Neuroscience, Karolinska Institutet
- Lijing Zhang
- BGI-Shenzhen
- Laura P. M. H. de Rooij
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB
- Lihua Luo
- BGI-Shenzhen
- Yanan Wei
- BGI-Shenzhen
- Wandong Zhao
- BGI-Shenzhen
- Zhiyuan Lv
- BGI-Shenzhen
- János Haskó
- Department of Biomedicine, Aarhus University
- Runchu Li
- BGI-Shenzhen
- Qiuyu Qin
- BGI-Shenzhen
- Yi Jia
- BGI-Shenzhen
- Wendi Wu
- BGI-Shenzhen
- Yuting Yuan
- School of Basic Medical Sciences, Binzhou Medical University
- Mingyi Pu
- BGI-Shenzhen
- Haoyu Wang
- BGI-Shenzhen
- Aiping Wu
- Institute of Systems Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College
- Lin Xie
- MGI, BGI-Shenzhen
- Ping Liu
- MGI, BGI-Shenzhen
- Fang Chen
- MGI, BGI-Shenzhen
- Jacqueline Herold
- Department of Biomedicine, Aarhus University
- Joanna Kalucka
- Department of Biomedicine, Aarhus University
- Max Karlsson
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology
- Xiuqing Zhang
- BGI-Shenzhen
- Rikke Bek Helmig
- Department of Obstetrics and Gynecology, Aarhus University Hospital
- Linn Fagerberg
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology
- Cecilia Lindskog
- Department of Immunology, Genetics and Pathology, Uppsala University
- Fredrik Pontén
- Department of Immunology, Genetics and Pathology, Uppsala University
- Mathias Uhlen
- Department of Neuroscience, Karolinska Institutet
- Lars Bolund
- Lars Bolund Institute of Regenerative Medicine, Qingdao-Europe Advanced Institute for Life Sciences, BGI-Qingdao, BGI-Shenzhen
- Niels Jessen
- Steno Diabetes Center Aarhus, Aarhus University Hospital
- Hui Jiang
- MGI, BGI-Shenzhen
- Xun Xu
- BGI-Shenzhen
- Huanming Yang
- BGI-Shenzhen
- Peter Carmeliet
- Department of Biomedicine, Aarhus University
- Jan Mulder
- Department of Neuroscience, Karolinska Institutet
- Dongsheng Chen
- BGI-Shenzhen
- Lin Lin
- Department of Biomedicine, Aarhus University
- Yonglun Luo
- Lars Bolund Institute of Regenerative Medicine, Qingdao-Europe Advanced Institute for Life Sciences, BGI-Qingdao, BGI-Shenzhen
- DOI
- https://doi.org/10.1038/s41467-022-31388-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Pigs are important large animal models for biomedical research. Here, the authors construct a single-cell landscape of pig tissues, unravelling the phenotypic heterogeneity of blood endothelial cells in adipose tissues and the evolutionally conserved regulons of microglia in brains.
