Induced human pluripotent stem cells (HEBHMUi013-A) derived from a patient of sporadic Alzheimer's disease

Shuxing Cao; Ruiyun Guo; Zewei Fu; Yukun Liu; Taotao Wu; Zijing Zhou; Jinyu Zhang; Xin Liu; Yongzhou Song; Jun Ma

Stem Cell Research (Apr 2023)

Induced human pluripotent stem cells (HEBHMUi013-A) derived from a patient of sporadic Alzheimer's disease

Shuxing Cao,
Ruiyun Guo,
Zewei Fu,
Yukun Liu,
Taotao Wu,
Zijing Zhou,
Jinyu Zhang,
Xin Liu,
Yongzhou Song,
Jun Ma

Affiliations

Shuxing Cao: The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050017, China
Ruiyun Guo: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Zewei Fu: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Yukun Liu: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Taotao Wu: Department of Pediatric, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China
Zijing Zhou: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Jinyu Zhang: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Xin Liu: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China
Yongzhou Song: The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.
Jun Ma: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-Galway University Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.

Journal volume & issue: Vol. 68
p. 103052

Abstract

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Sporadic Alzheimer’s disease (sAD) is the most common neurodegenerative disease worldwide, which is characterized by the progressive cognitive dysfunction and behavioral impairment. Here, we generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) isolated from a 78-year-old male patient clinically diagnosed with sAD. The iPSC line expressed pluripotency markers, showed normal karyotype, and had the ability to differentiate into three germ layers in vitro. This iPSC line may provide a powerful tool for modeling AD in vitro and studying the pathogenesis of sAD.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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