Percutaneous local injection of 0.1% pingyangmycin for treatment of oral vascular malformation in children

Abstract

Objective To investigate the clinical efficacy and safety of percutaneous local injection of 0.1% pingyangmycin for treatment of oral vascular malformation in children. Methods This retrospective study was conducted among 56 children with oral vascular malformation with complete clinical and follow-up data, who received treatment by percutaneous injection of 0.1% pingyangmycin between January, 2009 and December, 2015. In all the cases the dose of pingyangmycin was determined based on the size, depth and location of the tumors. The patients received the injections at the interval of 2-4 weeks, and in each case the number of the injections ranged from 1 to 16. The patients were followed up for 2 years after the last treatment to evaluate the therapeutic effects and adverse events related to the treatment. Results All the 56 children completed the whole treatment course. Forty-eight of the patients showed favorable response to the treatment, and 45 were basically cured; 7 patients failed to respond to the treatment. During the treatment, 4 patients experienced local ulcer and pigmentation; none of the patients showed severe adverse events related to the injections. The basic cure rate in these children was higher than the average rate reported in previous studies. Conclusion Percutaneous local injection of 0.1% pingyangmycin is a safe, effective and convenient treatment for oral vascular malformation in children.

Keywords

• pingyangmycin
• percutaneous injection
• oral vascular malformation