Frontiers in Bioengineering and Biotechnology (Jun 2023)
Comparison of bilateral differential characteristics of corneal biomechanics between keratoconus and normal eyes
- Yiyong Xian,
- Yiyong Xian,
- Yiyong Xian,
- Yiyong Xian,
- Yu Zhao,
- Yu Zhao,
- Yu Zhao,
- Yu Zhao,
- Ling Sun,
- Ling Sun,
- Ling Sun,
- Ling Sun,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Xiaoyu Zhang,
- Lan Ding,
- Lan Ding,
- Lan Ding,
- Lan Ding,
- Zesheng Liu,
- Zesheng Liu,
- Zesheng Liu,
- Zesheng Liu,
- Yuan Li,
- Yanlan Ding,
- Yanlan Ding,
- Yanlan Ding,
- Yanlan Ding,
- Lin Jiang,
- Lin Jiang,
- Lin Jiang,
- Lin Jiang,
- Xingtao Zhou,
- Xingtao Zhou,
- Xingtao Zhou,
- Xingtao Zhou,
- Yang Shen,
- Yang Shen,
- Yang Shen,
- Yang Shen
Affiliations
- Yiyong Xian
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Yiyong Xian
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Yiyong Xian
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Yiyong Xian
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Yu Zhao
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Yu Zhao
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Yu Zhao
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Yu Zhao
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Ling Sun
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Ling Sun
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Ling Sun
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Ling Sun
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Xiaoyu Zhang
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Xiaoyu Zhang
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Xiaoyu Zhang
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Xiaoyu Zhang
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Lan Ding
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Lan Ding
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Lan Ding
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Lan Ding
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Zesheng Liu
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Zesheng Liu
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Zesheng Liu
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Zesheng Liu
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Yuan Li
- Shangqiu First People’s Hospital, Shangqiu, China
- Yanlan Ding
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Yanlan Ding
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Yanlan Ding
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Yanlan Ding
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Lin Jiang
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Lin Jiang
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Lin Jiang
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Lin Jiang
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Xingtao Zhou
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Xingtao Zhou
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Xingtao Zhou
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Xingtao Zhou
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- Yang Shen
- Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China
- Yang Shen
- NHC Key Laboratory of Myopia, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China
- Yang Shen
- Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
- Yang Shen
- Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
- DOI
- https://doi.org/10.3389/fbioe.2023.1163223
- Journal volume & issue
-
Vol. 11
Abstract
Purpose: To compare bilateral differences in corneal biomechanics between keratoconus and normal eyes.Methods: In this case-control study, 346 eyes of 173 patients (aged 22.1 ± 6.1 years) with keratoconus (KC group) and 378 eyes of 189 patients (aged 26.7 ± 5.6 years) with ametropia (control group) were enrolled. Corneal tomography and biomechanical properties were examined using Pentacam HR and Corvis ST, respectively. The corneal biomechanical parameters were compared between eyes with forme fruste keratoconus (FFKC) and normal eyes. Bilateral differences in corneal biomechanical parameters were compared between the KC and control groups. Receiver operating characteristic (ROC) analysis was used to assess discriminative efficacies.Results: The areas under the ROC curves (AUROCs) of stiffness parameter at the first applanation (SP-A1) and Tomographic and Biomechanical Index (TBI) for identifying FFKC were 0.641 and 0.694, respectively. The bilateral differential values of major corneal biomechanical parameters were significantly increased in the KC group (all p < 0.05), except for the Corvis Biomechanical Index (CBI). The AUROCs of the bilateral differential values of the deformation amplitude ratio at 2 mm (ΔDAR2), Integrated Radius (ΔIR), SP-A1 (ΔSP-A1), and the maximum inverse concave radius (ΔMax ICR) for discriminating keratoconus were 0.889, 0.884, 0.826, and 0.805, respectively. The Logistic Regression Model-1 (comprising of ΔDAR2, ΔIR, and age) and the Logistic Regression Model-2 (comprising of ΔIR, ΔARTh, ΔBAD-D, and age) had AUROCs of 0.922 and 0.998, respectively, for discriminating keratoconus.Conclusion: The bilateral asymmetry of corneal biomechanics was significantly increased in keratoconus compared with normal eyes, which may be helpful for the early detection of keratoconus.
Keywords
