P115 Belimumab treatment rapidly restores B cell homeostasis and reduces atypical T-bet+ B cell expansion in patients with systemic lupus erythematosus

• Fabrizio Conti,
• Fulvia Ceccarelli,
• Marcella Visentini,
• Licia Picciariello,
• Francesco Natalucci,
• Francesca La Gualana,
• Gabriella Cusa,
• Giulio Olivieri,
• Begi Petriti,
• Maddalena Sciannamea

Affiliations

Fabrizio Conti

1Lupus Clinic, Division of Rheumatology, Dept. of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy

Fulvia Ceccarelli

1 Arthritis Center, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Sapienza University of Rome, Roma, Italy

Marcella Visentini

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Licia Picciariello

Lupus Clinic, Division of Rheumatology, Dept. of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy

Francesco Natalucci

Lupus Clinic, Division of Rheumatology, Dept. of Internal Clinical Sciences, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy

Francesca La Gualana

2Division of Clinical Immunology, Dept. of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Gabriella Cusa

2Division of Clinical Immunology, Dept. of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Giulio Olivieri

3Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; Chair of Pediatrics, Dept. of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy

Begi Petriti

2Division of Clinical Immunology, Dept. of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Maddalena Sciannamea

2Division of Clinical Immunology, Dept. of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy