Nature Communications (Sep 2022)
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
- M d Mesbah Uddin,
- Ngoc Quynh H. Nguyen,
- Bing Yu,
- Jennifer A. Brody,
- Akhil Pampana,
- Tetsushi Nakao,
- Myriam Fornage,
- Jan Bressler,
- Nona Sotoodehnia,
- Joshua S. Weinstock,
- Michael C. Honigberg,
- Daniel Nachun,
- Romit Bhattacharya,
- Gabriel K. Griffin,
- Varuna Chander,
- Richard A. Gibbs,
- Jerome I. Rotter,
- Chunyu Liu,
- Andrea A. Baccarelli,
- Daniel I. Chasman,
- Eric A. Whitsel,
- Douglas P. Kiel,
- Joanne M. Murabito,
- Eric Boerwinkle,
- Benjamin L. Ebert,
- Siddhartha Jaiswal,
- James S. Floyd,
- Alexander G. Bick,
- Christie M. Ballantyne,
- Bruce M. Psaty,
- Pradeep Natarajan,
- Karen N. Conneely
Affiliations
- M d Mesbah Uddin
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Ngoc Quynh H. Nguyen
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Bing Yu
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Akhil Pampana
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Tetsushi Nakao
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Jan Bressler
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Joshua S. Weinstock
- Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health
- Michael C. Honigberg
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Daniel Nachun
- Department of Pathology, Stanford University School of Medicine
- Romit Bhattacharya
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Gabriel K. Griffin
- Department of Pathology, Dana-Farber Cancer Institute
- Varuna Chander
- Human Genome Sequencing Center, Baylor College of Medicine
- Richard A. Gibbs
- Human Genome Sequencing Center, Baylor College of Medicine
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Chunyu Liu
- Department of Biostatistics, School of Public Health, Boston University
- Andrea A. Baccarelli
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University
- Daniel I. Chasman
- Department of Medicine, Harvard Medical School
- Eric A. Whitsel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Douglas P. Kiel
- Department of Medicine, Harvard Medical School
- Joanne M. Murabito
- Framingham Heart Study, Boston University and NHLBI/NIH
- Eric Boerwinkle
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Benjamin L. Ebert
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Siddhartha Jaiswal
- Department of Pathology, Stanford University School of Medicine
- James S. Floyd
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Alexander G. Bick
- Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center
- Christie M. Ballantyne
- Department of Medicine, Baylor College of Medicine
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Pradeep Natarajan
- Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT
- Karen N. Conneely
- Department of Human Genetics, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33093-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET2 mutations has directionally opposing changes in DNA methylation profiles, with both promoting stem cell self-renewal.
