Identifying Risk Factors for Native Coronary Atherosclerosis Progression After Percutaneous Coronary Intervention

Abstract

Objective: This study was aimed at investigating factors influencing the progression of native coronary atherosclerosis after percutaneous coronary intervention (PCI). Methods: A cohort of 462 patients was classified into progressive (n = 73) or non-progressive (n = 389) groups according to the presence of native coronary atherosclerosis progression on coronary angiography. Clinical data and angiography results were compared during follow-up, and the time to progression of native coronary atherosclerosis was recorded. Subsequently, multivariate Cox regression analysis was conducted. Results: In comparison to the non-progressive group, the progressive group had higher levels of glycosylated hemoglobin (HbA1c) and triglycerides (TG), and higher scores on the Synergy Between PCI with Taxus and Cardiac Surgery (SYNTAX) scale, but lower levels of high-density lipoprotein cholesterol. Moreover, the rates of hyperuricemia and acute coronary syndrome (ACS) were higher in the progressive group than the non-progressive group. Multivariate analysis identified ACS, HbA1c level ≥6.5%, TG level ≥5.6 mmol/L, and SYNTAX score ≥23 as risk factors for the progression of native coronary atherosclerosis. Conclusion: ACS, elevated HbA1c and TG levels, and higher SYNTAX scores may be associated with the progression of native coronary atherosclerosis after PCI.