Nature Communications (Jan 2021)

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

  • Hayley I. Muendlein,
  • Wilson M. Connolly,
  • Zoie Magri,
  • Irina Smirnova,
  • Vladimir Ilyukha,
  • Avishekh Gautam,
  • Alexei Degterev,
  • Alexander Poltorak

DOI
https://doi.org/10.1038/s41467-020-20357-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.