Communications Biology (May 2021)
Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice
- Prashanta Silwal,
- Jin Kyung Kim,
- Sang Min Jeon,
- June-Young Lee,
- Young Jae Kim,
- Yi Sak Kim,
- Yeji Seo,
- Jihye Kim,
- Soo Yeon Kim,
- Min Joung Lee,
- Jun Young Heo,
- Mi-Ja Jung,
- Hyun Sik Kim,
- Dong-Wook Hyun,
- Jeong Eun Han,
- Jake Whang,
- Yang Hoon Huh,
- Sang-Hee Lee,
- Won Do Heo,
- Jin-Man Kim,
- Jin-Woo Bae,
- Eun-Kyeong Jo
Affiliations
- Prashanta Silwal
- Department of Microbiology, Chungnam National University School of Medicine
- Jin Kyung Kim
- Department of Microbiology, Chungnam National University School of Medicine
- Sang Min Jeon
- Department of Microbiology, Chungnam National University School of Medicine
- June-Young Lee
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Young Jae Kim
- Department of Microbiology, Chungnam National University School of Medicine
- Yi Sak Kim
- Department of Medicine, University of California
- Yeji Seo
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
- Jihye Kim
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
- Soo Yeon Kim
- Future Medicine Division, Korea Institute of Oriental Medicine
- Min Joung Lee
- Infection Control Convergence Research Center, Chungnam National University School of Medicine
- Jun Young Heo
- Infection Control Convergence Research Center, Chungnam National University School of Medicine
- Mi-Ja Jung
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Hyun Sik Kim
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Dong-Wook Hyun
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Jeong Eun Han
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Jake Whang
- Korea Mycobacterium Resource Center (KMRC) & Basic Research Section, The Korean Institute of Tuberculosis (KIT)
- Yang Hoon Huh
- Center for Research Equipment, Korea Basic Science Institute
- Sang-Hee Lee
- Center for Research Equipment, Korea Basic Science Institute
- Won Do Heo
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
- Jin-Man Kim
- Department of Pathology, Chungnam National University School of Medicine
- Jin-Woo Bae
- Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University
- Eun-Kyeong Jo
- Department of Microbiology, Chungnam National University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-021-02073-6
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 17
Abstract
Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein is involved in host defense against intracellular bacterial infection.
