OncoImmunology (Aug 2019)

TEIPP peptides: exploration of unTAPped cancer antigens

  • Koen A. Marijt,
  • Sjoerd H. Van Der Burg,
  • Thorbald van Hall

DOI
https://doi.org/10.1080/2162402X.2019.1599639
Journal volume & issue
Vol. 8, no. 8

Abstract

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The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which ‘hidden‘ antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing.

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