Compound C inhibits the replication of feline coronavirus
Yeonjeong Park,
Chansoo Kim,
Yea-In Park,
Siyun Lee,
Jaeyeon So,
Rackhyun Park,
Junsoo Park
Affiliations
Yeonjeong Park
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
Chansoo Kim
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
Yea-In Park
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
Siyun Lee
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
Jaeyeon So
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
Rackhyun Park
Department of Life Science, Yong-In University, Yongin 17092, Republic of Korea
Junsoo Park
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea; Corresponding author. Yonsei University, Division of Biological Sciences and Technology 1 Yonseidae-gil, Wonju city, Kangwon province 26493, Republic of Korea.
Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20–60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, no effective treatments are available. We demonstrated that compound C (dorsomorphin) can potentially inhibit feline coronavirus replication. Compound C treatment decreased the FCoV-induced plaque formation and cytopathic effect in FCoV-infected cells. Compound C treatment also significantly reduced the amount of viral RNA and viral protein in the cells in a dose-dependent manner. Our findings suggest that compound C is potentially useful for feline coronavirus-related diseases.
