Nature Communications (Aug 2018)
Identification of nine new susceptibility loci for endometrial cancer
- Tracy A. O’Mara,
- Dylan M. Glubb,
- Frederic Amant,
- Daniela Annibali,
- Katie Ashton,
- John Attia,
- Paul L. Auer,
- Matthias W. Beckmann,
- Amanda Black,
- Manjeet K. Bolla,
- Hiltrud Brauch,
- Hermann Brenner,
- Louise Brinton,
- Daniel D. Buchanan,
- Barbara Burwinkel,
- Jenny Chang-Claude,
- Stephen J. Chanock,
- Chu Chen,
- Maxine M. Chen,
- Timothy H. T. Cheng,
- Christine L. Clarke,
- Mark Clendenning,
- Linda S. Cook,
- Fergus J. Couch,
- Angela Cox,
- Marta Crous-Bous,
- Kamila Czene,
- Felix Day,
- Joe Dennis,
- Jeroen Depreeuw,
- Jennifer Anne Doherty,
- Thilo Dörk,
- Sean C. Dowdy,
- Matthias Dürst,
- Arif B. Ekici,
- Peter A. Fasching,
- Brooke L. Fridley,
- Christine M. Friedenreich,
- Lin Fritschi,
- Jenny Fung,
- Montserrat García-Closas,
- Mia M. Gaudet,
- Graham G. Giles,
- Ellen L. Goode,
- Maggie Gorman,
- Christopher A. Haiman,
- Per Hall,
- Susan E. Hankison,
- Catherine S. Healey,
- Alexander Hein,
- Peter Hillemanns,
- Shirley Hodgson,
- Erling A. Hoivik,
- Elizabeth G. Holliday,
- John L. Hopper,
- David J. Hunter,
- Angela Jones,
- Camilla Krakstad,
- Vessela N. Kristensen,
- Diether Lambrechts,
- Loic Le Marchand,
- Xiaolin Liang,
- Annika Lindblom,
- Jolanta Lissowska,
- Jirong Long,
- Lingeng Lu,
- Anthony M. Magliocco,
- Lynn Martin,
- Mark McEvoy,
- Alfons Meindl,
- Kyriaki Michailidou,
- Roger L. Milne,
- Miriam Mints,
- Grant W. Montgomery,
- Rami Nassir,
- Håkan Olsson,
- Irene Orlow,
- Geoffrey Otton,
- Claire Palles,
- John R. B. Perry,
- Julian Peto,
- Loreall Pooler,
- Jennifer Prescott,
- Tony Proietto,
- Timothy R. Rebbeck,
- Harvey A. Risch,
- Peter A. W. Rogers,
- Matthias Rübner,
- Ingo Runnebaum,
- Carlotta Sacerdote,
- Gloria E. Sarto,
- Fredrick Schumacher,
- Rodney J. Scott,
- V. Wendy Setiawan,
- Mitul Shah,
- Xin Sheng,
- Xiao-Ou Shu,
- Melissa C. Southey,
- Anthony J. Swerdlow,
- Emma Tham,
- Jone Trovik,
- Constance Turman,
- Jonathan P. Tyrer,
- Celine Vachon,
- David VanDen Berg,
- Adriaan Vanderstichele,
- Zhaoming Wang,
- Penelope M. Webb,
- Nicolas Wentzensen,
- Henrica M. J. Werner,
- Stacey J. Winham,
- Alicja Wolk,
- Lucy Xia,
- Yong-Bing Xiang,
- Hannah P. Yang,
- Herbert Yu,
- Wei Zheng,
- Paul D. P. Pharoah,
- Alison M. Dunning,
- Peter Kraft,
- Immaculata De Vivo,
- Ian Tomlinson,
- Douglas F. Easton,
- Amanda B. Spurdle,
- Deborah J. Thompson
Affiliations
- Tracy A. O’Mara
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Dylan M. Glubb
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Frederic Amant
- Department of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology
- Daniela Annibali
- Department of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology
- Katie Ashton
- John Hunter Hospital, Hunter Medical Research Institute
- John Attia
- John Hunter Hospital, Hunter Medical Research Institute
- Paul L. Auer
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Matthias W. Beckmann
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN
- Amanda Black
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Manjeet K. Bolla
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Hiltrud Brauch
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Hermann Brenner
- German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Louise Brinton
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Daniel D. Buchanan
- Department of Clinical Pathology, The University of Melbourne
- Barbara Burwinkel
- Department of Obstetrics and Gynecology, University of Heidelberg
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Stephen J. Chanock
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Chu Chen
- Epidemiology Program, Fred Hutchinson Cancer Research Center
- Maxine M. Chen
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Timothy H. T. Cheng
- University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre
- Christine L. Clarke
- University of Sydney, Westmead Institute for Medical Research
- Mark Clendenning
- Department of Clinical Pathology, The University of Melbourne
- Linda S. Cook
- University of New Mexico, University of New Mexico Health Sciences Center
- Fergus J. Couch
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Angela Cox
- Department of Oncology and Metabolism, University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA)
- Marta Crous-Bous
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Kamila Czene
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Felix Day
- University of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine
- Joe Dennis
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Jeroen Depreeuw
- Department of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology
- Jennifer Anne Doherty
- Cancer Research Huntsman Cancer Institute Department of Population Health Sciences, University of Utah
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School
- Sean C. Dowdy
- Department of Obstetrics and Gynecology, Mayo Clinic, Division of Gynecologic Oncology
- Matthias Dürst
- Department of Gynaecology, Jena University Hospital - Friedrich Schiller University
- Arif B. Ekici
- Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen
- Peter A. Fasching
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN
- Brooke L. Fridley
- Department of Biostatistics, Kansas University Medical Center
- Christine M. Friedenreich
- Department of Cancer Epidemiology and Prevention Research, Alberta Health Services
- Lin Fritschi
- Curtin University, School of Public Health
- Jenny Fung
- University of Queensland, Institute for Molecular Bioscience
- Montserrat García-Closas
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Mia M. Gaudet
- American Cancer Society, Epidemiology Research Program
- Graham G. Giles
- The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health
- Ellen L. Goode
- Department of Health Science Research, Mayo Clinic, Division of Epidemiology
- Maggie Gorman
- University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre
- Christopher A. Haiman
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Susan E. Hankison
- Department of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women’s Hospital
- Catherine S. Healey
- Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Alexander Hein
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN
- Peter Hillemanns
- Gynaecology Research Unit, Hannover Medical School
- Shirley Hodgson
- Department of Clinical Genetics, St George’s, University of London
- Erling A. Hoivik
- Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers
- Elizabeth G. Holliday
- John Hunter Hospital, Hunter Medical Research Institute
- John L. Hopper
- The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health
- David J. Hunter
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Angela Jones
- University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre
- Camilla Krakstad
- Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers
- Vessela N. Kristensen
- Department of Cancer Genetics, Oslo University Hospital, Radiumhospitalet, Institute for Cancer Research
- Diether Lambrechts
- Department of Human Genetics, University of Leuven, Laboratory for Translational Genetics
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Xiaolin Liang
- Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center
- Annika Lindblom
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Jolanta Lissowska
- Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center-Oncology Institute
- Jirong Long
- Department of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center
- Lingeng Lu
- Chronic Disease Epidemiology, Yale School of Public Health
- Anthony M. Magliocco
- Department of Anatomic Pathology, Moffitt Cancer Center and Research Institute
- Lynn Martin
- University of Birmingham, Institute of Cancer and Genomic Sciences
- Mark McEvoy
- University of Newcastle, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health
- Alfons Meindl
- Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich
- Kyriaki Michailidou
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Roger L. Milne
- The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health
- Miriam Mints
- Department of Women’s and Children’s Health, Karolinska Institutet
- Grant W. Montgomery
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Rami Nassir
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Håkan Olsson
- Department of Cancer Epidemiology, Clinical Sciences, Lund University
- Irene Orlow
- Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center
- Geoffrey Otton
- University of Newcastle, School of Medicine and Public Health
- Claire Palles
- University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre
- John R. B. Perry
- University of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine
- Julian Peto
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Loreall Pooler
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Jennifer Prescott
- Department of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women’s Hospital
- Tony Proietto
- University of Newcastle, School of Medicine and Public Health
- Timothy R. Rebbeck
- Harvard T.H. Chan School of Public Health
- Harvey A. Risch
- Chronic Disease Epidemiology, Yale School of Public Health
- Peter A. W. Rogers
- Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women’s Hospital, Gynaecology Research Centre
- Matthias Rübner
- Department of Gynaecology and Obstetrics, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen
- Ingo Runnebaum
- Department of Gynaecology, Jena University Hospital - Friedrich Schiller University
- Carlotta Sacerdote
- Center for Cancer Prevention (CPO-Peimonte)
- Gloria E. Sarto
- Department of Obstetrics and Gynecology, University of Wisconsin, School of Medicine and Public Health
- Fredrick Schumacher
- Department of Epidemiology and Biostatistics, Case Western Reserve University
- Rodney J. Scott
- John Hunter Hospital, Hunter Medical Research Institute
- V. Wendy Setiawan
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Mitul Shah
- Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Xin Sheng
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Xiao-Ou Shu
- Department of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center
- Melissa C. Southey
- Department of Clinical Pathology, The University of Melbourne
- Anthony J. Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Emma Tham
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Jone Trovik
- Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers
- Constance Turman
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Jonathan P. Tyrer
- Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Celine Vachon
- Department of Health Sciences Research, Mayo Clinic
- David VanDen Berg
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Adriaan Vanderstichele
- Department of Obstetrics and Gynaecology, University Hospitals Leuven, Division of Gynecologic Oncology, Leuven Cancer Institute
- Zhaoming Wang
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Penelope M. Webb
- Department of Population Health, QIMR Berghofer Medical Research Institute
- Nicolas Wentzensen
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Henrica M. J. Werner
- Department of Clinical Science, University of Bergen, Centre for Cancer Biomarkers
- Stacey J. Winham
- Department of Health Science Research, Mayo Clinic, Division of Biomedical Statistics and Informatics
- Alicja Wolk
- Department of Environmental Medicine, Karolinska Institutet, Division of Nutritional Epidemiology
- Lucy Xia
- Department of Preventive Medicine, University of Southern California, Keck School of Medicine
- Yong-Bing Xiang
- Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, State Key Laboratory of Oncogene and Related Genes
- Hannah P. Yang
- National Cancer Institute, Division of Cancer Epidemiology and Genetics
- Herbert Yu
- Epidemiology Program, University of Hawaii Cancer Center
- Wei Zheng
- Department of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center
- Paul D. P. Pharoah
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Alison M. Dunning
- Department of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Immaculata De Vivo
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Ian Tomlinson
- University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre
- Douglas F. Easton
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- Amanda B. Spurdle
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Deborah J. Thompson
- Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology
- DOI
- https://doi.org/10.1038/s41467-018-05427-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Endometrial cancer is the most common invasive gynaecological cancer in developed countries. Here a meta-analysis identifies an additional nine novel endometrial cancer risk loci and eQTL analysis reveals risk variants associate with reduced expression of negative regulators of oncogenic signal transduction proteins.
