International Journal of General Medicine (May 2024)
Association of High apoB/apoA1 Ratio with Increased Erythrocytes, Platelet/Lymphocyte Ratio, D-dimer, Uric Acid and Cardiac Remodeling in Elderly Heart Failure Patients: A Retrospective Study
Abstract
Linping Wei,1 Jari A Laukkanen,2– 4 Yufeng Li,1 Xinrui Chen,1 Gang Li1 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, 70211, Finland; 3Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70211, Finland; 4Wellbeing Services County of Central Finland, Department of Medicine, Jyväskylä, 40620, FinlandCorrespondence: Gang Li, Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86 23 89011518, Fax +86 23 68811487, Email [email protected]; [email protected]: Previous studies have confirmed that high apolipoprotein B/apolipoprotein A1 (apoB/apoA1) ratio was associated with increased mortality from heart failure (HF). Furthermore, the association of plasma apoB/apoA1 ratio with clinical characteristics and adverse cardiac remodeling is still limited in chronic HF with mildly reduced ejection fraction (HFmrEF) elderly patients. Therefore, this study investigated the association of apoB/apoA1 ratio with clinical characteristics and adverse cardiac remodeling in chronic HFmrEF elderly patients.Methods: A total of 587 Chinese elderly (≥ 65 years) with coronary heart disease (CHD), HFmrEF (EF 40– 50%) and related blood biochemical data were collected retrospectively. The cross-sectional data of echocardiographic and blood parameters were compared between binary apoB/apoA1 groups.Results: In the elderly CHD patients with chronic HFmrEF, the univariate correlation analysis showed that apoB/apoA1 was correlated with younger age, increased prevalence of type 2 diabetes, erythrocytes, platelet/lymphocyte ratio (PLR), D-dimer, fibrinogen, high sensitivity C-reactive protein and uric acid, and adverse cardiac remodeling (All P < 0.05). However, multivariate logistic binary regression analysis found that high apoB/apoA1 ratio (≥ 0.62) was independently correlated with younger age, increased erythrocytes, PLR, D-dimer and uric acid, and adverse cardiac remodeling (All P < 0.05).Conclusion: In this retrospective study, the high apoB/apoA1 ratio is found to be associated with younger age, increased erythrocytes, PLR, D-dimer and uric acid, and adverse cardiac remodeling in Chinese CHD elderly with chronic HFmrEF.Keywords: apolipoprotein B, apolipoprotein A1, platelet/lymphocyte ratio, adverse cardiac remodeling, chronic heart failure, elderly
