Frontiers in Pharmacology (May 2017)
Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight
- Xiaorui Wu,
- Xiaorui Wu,
- Dong Li,
- Junlian Liu,
- Lihong Diao,
- Shukuan Ling,
- Yuheng Li,
- Jianyi Gao,
- Quanchun Fan,
- Weijia Sun,
- Qi Li,
- Dingsheng Zhao,
- Guohui Zhong,
- Dengchao Cao,
- Min Liu,
- Jiaping Wang,
- Shuang Zhao,
- Yu Liu,
- Guie Bai,
- Hongzhi Shi,
- Zi Xu,
- Jing Wang,
- Chunmei Xue,
- Xiaoyan Jin,
- Xinxin Yuan,
- Hongxing Li,
- Caizhi Liu,
- Huiyuan Sun,
- Jianwei Li,
- Yongzhi Li,
- Yongzhi Li,
- Yingxian Li
Affiliations
- Xiaorui Wu
- The Key Laboratory of Aerospace Medicine, Ministry of Education, The Fourth Military Medical UniversityXi’an, China
- Xiaorui Wu
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Dong Li
- State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing Proteome Research CenterBeijing, China
- Junlian Liu
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Lihong Diao
- State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing Proteome Research CenterBeijing, China
- Shukuan Ling
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Yuheng Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Jianyi Gao
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Quanchun Fan
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Weijia Sun
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Qi Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Dingsheng Zhao
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Guohui Zhong
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Dengchao Cao
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Min Liu
- Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical UniversityBeijing, China
- Jiaping Wang
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Shuang Zhao
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Yu Liu
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Guie Bai
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Hongzhi Shi
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Zi Xu
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Jing Wang
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Chunmei Xue
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Xiaoyan Jin
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Xinxin Yuan
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Hongxing Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Caizhi Liu
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Huiyuan Sun
- Xiyuan Hospital, China Academy of Chinese Medical SciencesBeijing, China
- Jianwei Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Yongzhi Li
- The Key Laboratory of Aerospace Medicine, Ministry of Education, The Fourth Military Medical UniversityXi’an, China
- Yongzhi Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- Yingxian Li
- State Key Laboratory of Space Medicine Fundamentals and Applications, China Astronaut Research and Training CenterBeijing, China
- DOI
- https://doi.org/10.3389/fphar.2017.00315
- Journal volume & issue
-
Vol. 8
Abstract
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but the underlying mechanisms and countermeasures need to be explored. In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE), which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury. Bioinformatics combined with experimental verification identified that the PI3K-Akt-mTOR pathway was inhibited and the MAPK pathway was activated during SLSE-induced cognition dysfunction, whereas DS substantially ameliorated the changes in brain. These findings defined the characteristics of SLSE-induced cognitive decline and the mechanisms by which DS improves it. The results provide an effective candidate for improving cognitive function in spaceflight missions.
Keywords
