BMC Medicine (Feb 2022)
Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development
- Daniel Munblit,
- Timothy R. Nicholson,
- Dale M. Needham,
- Nina Seylanova,
- Callum Parr,
- Jessica Chen,
- Alisa Kokorina,
- Louise Sigfrid,
- Danilo Buonsenso,
- Shinjini Bhatnagar,
- Ramachandran Thiruvengadam,
- Ann M. Parker,
- Jacobus Preller,
- Sergey Avdeev,
- Frederikus A. Klok,
- Allison Tong,
- Janet V. Diaz,
- Wouter De Groote,
- Nicoline Schiess,
- Athena Akrami,
- Frances Simpson,
- Piero Olliaro,
- Christian Apfelbacher,
- Regis Goulart Rosa,
- Jennifer R. Chevinsky,
- Sharon Saydah,
- Jochen Schmitt,
- Alla Guekht,
- Sarah L. Gorst,
- Jon Genuneit,
- Luis Felipe Reyes,
- Alan Asmanov,
- Margaret E. O’Hara,
- Janet T. Scott,
- Melina Michelen,
- Charitini Stavropoulou,
- John O. Warner,
- Margaret Herridge,
- Paula R. Williamson
Affiliations
- Daniel Munblit
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Timothy R. Nicholson
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Dale M. Needham
- Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University
- Nina Seylanova
- Sechenov Biomedical Science and Technology Park, Sechenov First Moscow State Medical University (Sechenov University)
- Callum Parr
- Faculty of Medicine, Imperial College London
- Jessica Chen
- Faculty of Medicine, Imperial College London
- Alisa Kokorina
- Pirogov Russian National Research Medical University
- Louise Sigfrid
- ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford
- Danilo Buonsenso
- Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS
- Shinjini Bhatnagar
- Maternal and Child Health Program, Translational Health Science and Technology Institute
- Ramachandran Thiruvengadam
- Maternal and Child Health Program, Translational Health Science and Technology Institute
- Ann M. Parker
- Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University
- Jacobus Preller
- Clinical Management, WHO, WHE
- Sergey Avdeev
- Department of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University)
- Frederikus A. Klok
- Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center
- Allison Tong
- Sydney School of Public Health, The University of Sydney
- Janet V. Diaz
- NCD Department, Rehabilitation Programme, WHO
- Wouter De Groote
- NCD Department, Rehabilitation Programme, WHO
- Nicoline Schiess
- WHO Brain Health Unit
- Athena Akrami
- Sainsbury Wellcome Centre, UCL
- Frances Simpson
- Coventry University
- Piero Olliaro
- ISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford
- Christian Apfelbacher
- Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg
- Regis Goulart Rosa
- Critical Care Department, Hospital Moinhos de Vento
- Jennifer R. Chevinsky
- COVID-19 Response Team, Centers for Disease Control and Prevention
- Sharon Saydah
- COVID-19 Response Team, Centers for Disease Control and Prevention
- Jochen Schmitt
- Center for Evidence-Based Healthcare, Medical Faculty Carl Gustav Carus, TU Dresden
- Alla Guekht
- Research and Clinical Center for Neuropsychiatry
- Sarah L. Gorst
- Department of Health Data Science, University of Liverpool
- Jon Genuneit
- Paediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University
- Luis Felipe Reyes
- Universidad de La Sabana
- Alan Asmanov
- The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Pirogov Russian National Research Medical University
- Margaret E. O’Hara
- Long COVID Support
- Janet T. Scott
- MRC-University of Glasgow, Centre for Virus Research
- Melina Michelen
- ISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford
- Charitini Stavropoulou
- School of Health Sciences, City, University of London
- John O. Warner
- Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust
- Margaret Herridge
- Interdepartmental Division of Critical Care Medicine, University of Toronto
- Paula R. Williamson
- MRC/NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool (a member of Liverpool Health Partners)
- DOI
- https://doi.org/10.1186/s12916-021-02222-y
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 13
Abstract
Abstract Background A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden. Main text While the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data. Conclusions A Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.
Keywords
- COVID-19
- COVID-19 sequalae
- Long COVID
- Post-acute sequelae of SARS-CoV-2 infection
- PASC
- Post-COVID-19 condition
