DYNAMIC EVALUATION CONDITION OF RENAL PARENCHYMA IN PATIENTS AFTER EXTERNAL SHOCK WAVE LITHOTRIPSY OF KIDNEY STONES

Abstract

The study includes the results of treatment of 167 patients with nephrolithiasis: first group included 80 patients with 1 session of extracorporeal shock wave lithotripsy (ESWL), the second group consisted of 87 patients who underwent 2-4 session ESWL. All patients underwent duplex scanning in renal blood flow, was determined by the concentration of serum creatinine and estimate the glomerular filtration rate. ELISA also investigated the dynamics of the content of lipocalin-2 (NGAL) and β2-microglobulin. All studies were performed at 5-7, 10-14, and 1-3 months after treatment. It is shown that in case of ESWL occurs renal parenchymal damage of varying degree, aggravated by increasing the number of sessions. By the early markers of acute kidney injury in patients with nephrolithiasis should include an increase urinary excretion of β2-MG and NGAL. Results of dynamic duplex scanning can reveal the underlying mechanisms of progression of renal dysfunction in patients after ESWL.

Keywords

• nephrolithiasis
• extracorporeal shock wave lithotripsy
• kidney damage