Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes

Guan A. Wang; Xiaoyu Xie; Hayam Mansour; Fangfang Chen; Gabriela Matamoros; Ana L. Sanchez; Chunhai Fan; Feng Li

doi:10.1038/s41467-020-19269-9

Nature Communications (Oct 2020)

Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes

Guan A. Wang,
Xiaoyu Xie,
Hayam Mansour,
Fangfang Chen,
Gabriela Matamoros,
Ana L. Sanchez,
Chunhai Fan,
Feng Li

Affiliations

Guan A. Wang: Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University
Xiaoyu Xie: Department of Chemistry, Centre for Biotechnology, Brock University
Hayam Mansour: Department of Chemistry, Centre for Biotechnology, Brock University
Fangfang Chen: Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University
Gabriela Matamoros: Department of Health Sciences, Brock University
Ana L. Sanchez: Department of Health Sciences, Brock University
Chunhai Fan: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Feng Li: Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University

DOI: https://doi.org/10.1038/s41467-020-19269-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The design of nucleic acid hybridisation probes is important for their use in DNA nanotechnology and biomedical applications. Here the authors use a DNA equalizer gate approach that expands the detection windows for improved sequence selectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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