Alzheimer’s Research & Therapy (Feb 2021)

Cognitive trajectories of patients with focal ß-amyloid deposition

  • Si Eun Kim,
  • Byungju Lee,
  • Hyemin Jang,
  • Juhee Chin,
  • Ching Soong Khoo,
  • Yeong Sim Choe,
  • Ji Sun Kim,
  • Sung Hoon Kang,
  • Hang-Rai Kim,
  • Song Hwangbo,
  • Jee Hyang Jeong,
  • Soo Jin Yoon,
  • Kyung Won Park,
  • Eun-Joo Kim,
  • Bora Yoon,
  • Jae-Won Jang,
  • Jin Yong Hong,
  • Duk L. Na,
  • Sang Won Seo,
  • Seong Hye Choi,
  • Hee Jin Kim

DOI
https://doi.org/10.1186/s13195-021-00787-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Abstract Background The presence of ß-amyloid (Aß) in the brain can be identified using amyloid PET. In clinical practice, the amyloid PET is interpreted based on dichotomous visual rating, which renders focal Aß accumulation be read as positive for Aß. However, the prognosis of patients with focal Aß deposition is not well established. Thus, we investigated cognitive trajectories of patients with focal Aß deposition. Methods We followed up 240 participants (112 cognitively unimpaired [CU], 78 amnestic mild cognitive impairment [aMCI], and 50 Alzheimer’s disease (AD) dementia [ADD]) for 2 years from 9 referral centers in South Korea. Participants were assessed with neuropsychological tests and 18F-flutemetamol (FMM) positron emission tomography (PET). Ten regions (frontal, precuneus/posterior cingulate (PPC), lateral temporal, parietal, and striatum of each hemisphere) were visually examined in the FMM scan, and participants were divided into three groups: No-FMM, Focal-FMM (FMM uptake in 1–9 regions), and Diffuse-FMM. We used mixed-effects model to investigate the speed of cognitive decline in the Focal-FMM group according to the cognitive level, extent, and location of Aß involvement, in comparison with the No- or Diffuse-FMM group. Results Forty-five of 240 (18.8%) individuals were categorized as Focal-FMM. The rate of cognitive decline in the Focal-FMM group was faster than the No-FMM group (especially in the CU and aMCI stage) and slower than the Diffuse-FMM group (in particular in the CU stage). Within the Focal-FMM group, participants with FMM uptake to a larger extent (7–9 regions) showed faster cognitive decline compared to those with uptake to a smaller extent (1–3 or 4–6 regions). The Focal-FMM group was found to have faster cognitive decline in comparison with the No-FMM when there was uptake in the PPC, striatum, and frontal cortex. Conclusions When predicting cognitive decline of patients with focal Aß deposition, the patients’ cognitive level, extent, and location of the focal involvement are important.

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