Nature Communications (Dec 2020)
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
- Niyati Desai,
- Azfar Neyaz,
- Annamaria Szabolcs,
- Angela R. Shih,
- Jonathan H. Chen,
- Vishal Thapar,
- Linda T. Nieman,
- Alexander Solovyov,
- Arnav Mehta,
- David J. Lieb,
- Anupriya S. Kulkarni,
- Christopher Jaicks,
- Katherine H. Xu,
- Michael J. Raabe,
- Christopher J. Pinto,
- Dejan Juric,
- Ivan Chebib,
- Robert B. Colvin,
- Arthur Y. Kim,
- Robert Monroe,
- Sarah E. Warren,
- Patrick Danaher,
- Jason W. Reeves,
- Jingjing Gong,
- Erroll H. Rueckert,
- Benjamin D. Greenbaum,
- Nir Hacohen,
- Stephen M. Lagana,
- Miguel N. Rivera,
- Lynette M. Sholl,
- James R. Stone,
- David T. Ting,
- Vikram Deshpande
Affiliations
- Niyati Desai
- Massachusetts General Hospital Cancer Center
- Azfar Neyaz
- Massachusetts General Hospital Cancer Center
- Annamaria Szabolcs
- Massachusetts General Hospital Cancer Center
- Angela R. Shih
- Department of Pathology, Massachusetts General Hospital
- Jonathan H. Chen
- Massachusetts General Hospital Cancer Center
- Vishal Thapar
- Massachusetts General Hospital Cancer Center
- Linda T. Nieman
- Massachusetts General Hospital Cancer Center
- Alexander Solovyov
- Memorial Sloan Kettering Cancer Center
- Arnav Mehta
- Massachusetts General Hospital Cancer Center
- David J. Lieb
- The Broad Institute
- Anupriya S. Kulkarni
- Massachusetts General Hospital Cancer Center
- Christopher Jaicks
- Massachusetts General Hospital Cancer Center
- Katherine H. Xu
- Massachusetts General Hospital Cancer Center
- Michael J. Raabe
- Massachusetts General Hospital Cancer Center
- Christopher J. Pinto
- Massachusetts General Hospital Cancer Center
- Dejan Juric
- Massachusetts General Hospital Cancer Center
- Ivan Chebib
- Department of Pathology, Massachusetts General Hospital
- Robert B. Colvin
- Department of Pathology, Massachusetts General Hospital
- Arthur Y. Kim
- Department of Medicine, Massachusetts General Hospital
- Robert Monroe
- Advanced Cell Diagnostics, a Bio-Techne Brand
- Sarah E. Warren
- NanoString Inc.
- Patrick Danaher
- NanoString Inc.
- Jason W. Reeves
- NanoString Inc.
- Jingjing Gong
- NanoString Inc.
- Erroll H. Rueckert
- NanoString Inc.
- Benjamin D. Greenbaum
- Memorial Sloan Kettering Cancer Center
- Nir Hacohen
- Massachusetts General Hospital Cancer Center
- Stephen M. Lagana
- Department of Pathology and Cell Biology, Columbia University Irving Medical Center
- Miguel N. Rivera
- Massachusetts General Hospital Cancer Center
- Lynette M. Sholl
- Department of Pathology, Brigham and Woman’s Hospital
- James R. Stone
- Department of Pathology, Massachusetts General Hospital
- David T. Ting
- Massachusetts General Hospital Cancer Center
- Vikram Deshpande
- Massachusetts General Hospital Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-20139-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage.
