A Rare Case of Primary Bone Follicular Lymphoma with Multiple Osteolytic Lesions: A Case Report and Review of the Literature
Chiara Togni,
Giacinto La Verde,
Sabrina Pelliccia,
Maria Paola Bianchi,
Arianna Di Napoli,
Tiziana Lanzolla,
Marta Zerunian,
Andrea Laghi,
Gianluca Maiorana,
Ambra Taglietti,
Agostino Tafuri
Affiliations
Chiara Togni
Hematology, Department of Translational and Precision Medicine, Sapienza University, 00185 Rome, Italy
Giacinto La Verde
Hematology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Sabrina Pelliccia
Hematology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Maria Paola Bianchi
Hematology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Arianna Di Napoli
Pathology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Tiziana Lanzolla
Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Marta Zerunian
Radiology Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, 00189 Rome, Italy
Andrea Laghi
Radiology Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, 00189 Rome, Italy
Gianluca Maiorana
Hematology, Department of Translational and Precision Medicine, Sapienza University, 00185 Rome, Italy
Ambra Taglietti
Hematology, Department of Translational and Precision Medicine, Sapienza University, 00185 Rome, Italy
Agostino Tafuri
Hematology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, Sapienza University, 00189 Rome, Italy
Introduction: Primary bone lymphoma (PBL) is a rare clinical entity, accounting for less than 5% of all extranodal non-Hodgkin lymphomas and approximately 5% of primary bone tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common histotype, accounting for about 80% of all PBL cases. Conversely, the incidence of indolent primary bone lymphomas (iPBL) represents less than 1% of all reported PBL cases, and data on these rarer lymphomas are scarce. Drawing on diagnostic criteria developed by the World Health Organization (WHO) and the International Extranodal Lymphoma Study Group (IELSG), we report a rare case of primary bone follicular lymphoma, focusing specifically on the clinical presentation and treatment. Discussion: Additionally, we provide a systematic review of the literature data on this very rare lymphoproliferative entity.
