Nature Communications (Jun 2020)
Transplantation of discarded livers following viability testing with normothermic machine perfusion
- Hynek Mergental,
- Richard W. Laing,
- Amanda J. Kirkham,
- M. Thamara P. R. Perera,
- Yuri L. Boteon,
- Joseph Attard,
- Darren Barton,
- Stuart Curbishley,
- Manpreet Wilkhu,
- Desley A. H. Neil,
- Stefan G. Hübscher,
- Paolo Muiesan,
- John R. Isaac,
- Keith J. Roberts,
- Manuel Abradelo,
- Andrea Schlegel,
- James Ferguson,
- Hentie Cilliers,
- Julian Bion,
- David H. Adams,
- Chris Morris,
- Peter J. Friend,
- Christina Yap,
- Simon C. Afford,
- Darius F. Mirza
Affiliations
- Hynek Mergental
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Richard W. Laing
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Amanda J. Kirkham
- Cancer Research UK Clinical Trials Unit, University of Birmingham
- M. Thamara P. R. Perera
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Yuri L. Boteon
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Joseph Attard
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Darren Barton
- D3B team, Cancer Research UK Clinical Trials Unit, University of Birmingham
- Stuart Curbishley
- National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust
- Manpreet Wilkhu
- D3B team, Cancer Research UK Clinical Trials Unit, University of Birmingham
- Desley A. H. Neil
- National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust
- Stefan G. Hübscher
- National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust
- Paolo Muiesan
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- John R. Isaac
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Keith J. Roberts
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Manuel Abradelo
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Andrea Schlegel
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- James Ferguson
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Hentie Cilliers
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Julian Bion
- Department of Intensive Care Medicine, University of Birmingham
- David H. Adams
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- Chris Morris
- OrganOx Limited
- Peter J. Friend
- OrganOx Limited
- Christina Yap
- Cancer Research UK Clinical Trials Unit, University of Birmingham
- Simon C. Afford
- National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust
- Darius F. Mirza
- Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT)
- DOI
- https://doi.org/10.1038/s41467-020-16251-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The shortage of viable donated livers limits patient access to liver transplantation. Here the authors report the use of normothermic machine perfusion to help identify viable organs from livers discarded based on current clinical criteria, which are then transplanted to recipients in a single-arm clinical trial.
