Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus
Kuanysh Dossybayeva,
Yergali Bexeitov,
Zaure Mukusheva,
Zhaina Almukhamedova,
Maykesh Assylbekova,
Diyora Abdukhakimova,
Marzhan Rakhimzhanova,
Dimitri Poddighe
Affiliations
Kuanysh Dossybayeva
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan
Yergali Bexeitov
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan
Zaure Mukusheva
Program of Pediatric Rheumatology, Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan 010000, Kazakhstan
Zhaina Almukhamedova
Program of Pediatric Rheumatology, Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan 010000, Kazakhstan
Maykesh Assylbekova
Program of Pediatric Rheumatology, Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan 010000, Kazakhstan
Diyora Abdukhakimova
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan
Marzhan Rakhimzhanova
Program of Pediatric Endocrinology and Inherited Diseases, Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan 010000, Kazakhstan
Dimitri Poddighe
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan
Basophils are the least abundant circulating leukocytes, and their immunological role has not yet been completely elucidated. There is evidence supporting their immunomodulatory role in several pathological settings; recently, studies in both experimental models and humans suggested that basophil homeostasis may be altered in systemic lupus erythematosus (SLE). Here, we first assessed circulating basophils in children affected with pediatric SLE (pSLE). In this cross-sectional study, circulating basophils were enumerated by fluorescence-based flow cytometry analysis in children affected with pSLE, in addition to children suffering from juvenile idiopathic arthritis (JIA) or non-inflammatory/non-rheumatic conditions. This study included 52 pediatric patients distributed in these three groups. We observed a statistically significant reduction of peripherally circulating basophils in children with pSLE compared to the other two groups of patients. This preliminary study is consistent with the available studies in adult patients with SLE showing a reduced number of circulating basophils. However, further research is needed to draw final conclusions on basophils’ homeostasis in pSLE, in addition to their correlation with the disease activity and concomitant therapies.
