Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation

Karen Brami-Cherrier; Robert G. Lewis; Marlene Cervantes; Yu Liu; Paola Tognini; Pierre Baldi; Paolo Sassone-Corsi; Emiliana Borrelli

doi:10.1038/s41467-020-18200-6

Nature Communications (Sep 2020)

Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation

Karen Brami-Cherrier,
Robert G. Lewis,
Marlene Cervantes,
Yu Liu,
Paola Tognini,
Pierre Baldi,
Paolo Sassone-Corsi,
Emiliana Borrelli

Affiliations

Karen Brami-Cherrier: Center for Epigenetics and Metabolism, INSERM U1233, Department of Microbiology and Molecular Genetics, University of California Irvine
Robert G. Lewis: Center for Epigenetics and Metabolism, INSERM U1233, Department of Microbiology and Molecular Genetics, University of California Irvine
Marlene Cervantes: Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, University of California Irvine
Yu Liu: Institute for Genomics and Bioinformatics, Department of Computer Science, University of California Irvine
Paola Tognini: Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, University of California Irvine
Pierre Baldi: Institute for Genomics and Bioinformatics, Department of Computer Science, University of California Irvine
Paolo Sassone-Corsi: Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, University of California Irvine
Emiliana Borrelli: Center for Epigenetics and Metabolism, INSERM U1233, Department of Microbiology and Molecular Genetics, University of California Irvine

DOI: https://doi.org/10.1038/s41467-020-18200-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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