Changes in the structural and functional state of the myocardium and intracardiac hemodynamics as markers of cardiovascular risks in adolescent children with obesity and metabolic syndrome

Abstract

Obesity is one of the high-priority problems in modern pediatrics. To study early cardiovascular risks in adolescent children with obesity, 85 subjects with exogenous constitutional obesity at the age of 12–18 years were examined. The patients were divided into two groups: the first group, 41 patients with uncomplicated primary exogenous constitutional obesity, the second — 44 patients with obesity and metabolic syndrome; controls included 20 healthy adolescents of the same age with normal body weight. Based on a comprehensive study of the structural and functional state of the myocardium and intracardiac hemodynamics, it was found that the early significant criteria for cardiovascular risk in obese adolescent children were insulin resistance (HOMA-IR over 3.4), labile arterial hypertension, impaired relaxation, and/or concentric LV remodeling.

Keywords

• дети
• подростки
• ожирение
• метаболический синдром
• гиперинсулинемия
• структурно-функциональное состояние сердца