Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy

• Kazuhide Sato,
• Kanta Ando,
• Shuhei Okuyama,
• Shiho Moriguchi,
• Tairo Ogura,
• Shinichiro Totoki,
• Hirofumi Hanaoka,
• Tadanobu Nagaya,
• Ryohei Kokawa,
• Hideo Takakura,
• Masayuki Nishimura,
• Yoshinori Hasegawa,
• Peter L. Choyke,
• Mikako Ogawa,
• Hisataka Kobayashi

Affiliations

Kazuhide Sato

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Kanta Ando

Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

Shuhei Okuyama

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Shiho Moriguchi

Shimadzu Corporation, Kyoto, Japan

Tairo Ogura

Shimadzu Corporation, Kyoto, Japan

Shinichiro Totoki

Shimadzu Corporation, Kyoto, Japan

Hirofumi Hanaoka

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Tadanobu Nagaya

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Ryohei Kokawa

Shimadzu Corporation, Kyoto, Japan

Hideo Takakura

Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

Masayuki Nishimura

Shimadzu Corporation, Kyoto, Japan

Yoshinori Hasegawa

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

Peter L. Choyke

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

Mikako Ogawa

Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan

Hisataka Kobayashi

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States