A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

Joana F. Campos; Mohammed Loubidi; Marie-Christine Scherrmann; Sabine Berteina-Raboin

doi:10.3390/molecules23030684

Molecules (Mar 2018)

A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

Joana F. Campos,
Mohammed Loubidi,
Marie-Christine Scherrmann,
Sabine Berteina-Raboin

Affiliations

Joana F. Campos: Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France
Mohammed Loubidi: Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France
Marie-Christine Scherrmann: Institute of Molecular Chemistry and Materials of Orsay, UMR CNRS 8182, University of Paris-Sud, Building 420, 91400 Orsay, France
Sabine Berteina-Raboin: Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France

DOI: https://doi.org/10.3390/molecules23030684
Journal volume & issue: Vol. 23, no. 3
p. 684

Abstract

Read online

A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords