Biological Activity of Liposomal Silibinin

Abstract

The aim of the study was to obtain and characterize liposomal silibinin, as well as to study its antitumor and antimicrobial activity. Liposomes were obtained by hydration of a thin-layer film with a buffer solution followed by multiple freezing-thawing of the dispersion of phosphatidylcholine-cholesterol-silibinin. It has been established that liposomal silibinin has an inhibitory effect against liver (HepG2 line) and prostate gland (DU145 line) tumor cells. In addition, liposomalosilinin has a pronounced antibacterial effect against bacteria and a fungistatic effect on toxigenic micromycetes, which may indicate its effectiveness as an antimicrobial and fungistatic agent for reducing the negative effect of mycotoxins of mold fungi.

Keywords

• silibinin
• liposomes
• antitumor activity
• antimicrobial activity