Communications Medicine (Feb 2023)

Strain-level bacterial typing directly from patient samples using optical DNA mapping

  • My Nyblom,
  • Anna Johnning,
  • Karolin Frykholm,
  • Marie Wrande,
  • Vilhelm Müller,
  • Gaurav Goyal,
  • Miriam Robertsson,
  • Albertas Dvirnas,
  • Tsegaye Sewunet,
  • Sriram KK,
  • Tobias Ambjörnsson,
  • Christian G. Giske,
  • Linus Sandegren,
  • Erik Kristiansson,
  • Fredrik Westerlund

DOI
https://doi.org/10.1038/s43856-023-00259-z
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 10

Abstract

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Nyblom, Johnning et al. develop an optical DNA mapping approach for bacterial strain typing of patient samples. They demonstrate rapid identification of clinically relevant E. coli and K. pneumoniae strains, without the need for cultivation.