Wellcome Open Research (Apr 2020)
Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment [version 1; peer review: 2 approved]
- Kylie E C Ainslie,
- Caroline E. Walters,
- Han Fu,
- Sangeeta Bhatia,
- Haowei Wang,
- Xiaoyue Xi,
- Marc Baguelin,
- Samir Bhatt,
- Adhiratha Boonyasiri,
- Olivia Boyd,
- Lorenzo Cattarino,
- Constanze Ciavarella,
- Zulma Cucunuba,
- Gina Cuomo-Dannenburg,
- Amy Dighe,
- Ilaria Dorigatti,
- Sabine L van Elsland,
- Rich FitzJohn,
- Katy Gaythorpe,
- Azra C Ghani,
- Will Green,
- Arran Hamlet,
- Wes Hinsley,
- Natsuko Imai,
- David Jorgensen,
- Edward Knock,
- Daniel Laydon,
- Gemma Nedjati-Gilani,
- Lucy C Okell,
- Igor Siveroni,
- Hayley A Thompson,
- H Juliette T Unwin,
- Robert Verity,
- Michaela Vollmer,
- Patrick G T Walker,
- Yuanrong Wang,
- Oliver J Watson,
- Charles Whittaker,
- Peter Winskill,
- Christl A Donnelly,
- Neil M Ferguson,
- Steven Riley
Affiliations
- Kylie E C Ainslie
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Caroline E. Walters
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Han Fu
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Sangeeta Bhatia
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Haowei Wang
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Xiaoyue Xi
- Department of Mathematics, Imperial College London, London, SW7 2AZ, UK
- Marc Baguelin
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Samir Bhatt
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Adhiratha Boonyasiri
- NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, SW7 2AZ, UK
- Olivia Boyd
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Lorenzo Cattarino
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Constanze Ciavarella
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Zulma Cucunuba
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Gina Cuomo-Dannenburg
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Amy Dighe
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Ilaria Dorigatti
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Sabine L van Elsland
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Rich FitzJohn
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Katy Gaythorpe
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Azra C Ghani
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Will Green
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Arran Hamlet
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Wes Hinsley
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Natsuko Imai
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- David Jorgensen
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Edward Knock
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Daniel Laydon
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Gemma Nedjati-Gilani
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Lucy C Okell
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Igor Siveroni
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Hayley A Thompson
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- H Juliette T Unwin
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Robert Verity
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Michaela Vollmer
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Patrick G T Walker
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Yuanrong Wang
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Oliver J Watson
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Charles Whittaker
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Peter Winskill
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Christl A Donnelly
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Neil M Ferguson
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- Steven Riley
- MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1PG, UK
- DOI
- https://doi.org/10.12688/wellcomeopenres.15843.1
- Journal volume & issue
-
Vol. 5
Abstract
Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city of Wuhan, Hubei, China imposed strict social distancing in Wuhan on 23 January 2020 followed closely by similar measures in other provinces. These interventions have impacted economic productivity in China, and the ability of the Chinese economy to resume without restarting the epidemic was not clear. Methods: Using daily reported cases from mainland China and Hong Kong SAR, we estimated transmissibility over time and compared it to daily within-city movement, as a proxy for economic activity. Results: Initially, within-city movement and transmission were very strongly correlated in the five mainland provinces most affected by the epidemic and Beijing. However, that correlation decreased rapidly after the initial sharp fall in transmissibility. In general, towards the end of the study period, the correlation was no longer apparent, despite substantial increases in within-city movement. A similar analysis for Hong Kong shows that intermediate levels of local activity were maintained while avoiding a large outbreak. At the very end of the study period, when China began to experience the re-introduction of a small number of cases from Europe and the United States, there is an apparent up-tick in transmission. Conclusions: Although these results do not preclude future substantial increases in incidence, they suggest that after very intense social distancing (which resulted in containment), China successfully exited its lockdown to some degree. Elsewhere, movement data are being used as proxies for economic activity to assess the impact of interventions. The results presented here illustrate how the eventual decorrelation between transmission and movement is likely a key feature of successful COVID-19 exit strategies.