Haematologica (May 2014)
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients
- Julie Damgaard Sandahl,
- Eva A. Coenen,
- Erik Forestier,
- Jochen Harbott,
- Bertil Johansson,
- Gitte Kerndrup,
- Souichi Adachi,
- Anne Auvrignon,
- H. Berna Beverloo,
- Jean-Michel Cayuela,
- Lucy Chilton,
- Maarten Fornerod,
- Valérie de Haas,
- Christine J. Harrison,
- Hiroto Inaba,
- Gertjan J.L. Kaspers,
- Der-Cherng Liang,
- Franco Locatelli,
- Riccardo Masetti,
- Christine Perot,
- Susana C. Raimondi,
- Katarina Reinhardt,
- Daisuke Tomizawa,
- Nils von Neuhoff,
- Marco Zecca,
- C. Michel Zwaan,
- Marry M. van den Heuvel-Eibrink,
- Henrik Hasle
Affiliations
- Julie Damgaard Sandahl
- Department of Pediatrics, Aarhus University Hospital Skejby, Denmark
- Eva A. Coenen
- Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands
- Erik Forestier
- Department of Medical Biosciences, Genetics, Umeå University Hospital, Sweden
- Jochen Harbott
- Department of Pediatric Hematology/Oncology, Justus-Liebig-University, Giessen, Germany
- Bertil Johansson
- Department of Clinical Genetics, University and Regional Laboratories Region Skåne, Lund, and Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Sweden
- Gitte Kerndrup
- Department of Pathology, Vejle Hospital, Denmark
- Souichi Adachi
- Human Health Sciences, Kyoto University, Japan
- Anne Auvrignon
- French Leucémie Aique Myeloide Enfant, Hôpital Trousseau, Paris, France
- H. Berna Beverloo
- Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands;Dutch Childhood Oncology Group, Dutch Working Group on Hemato-Oncologic Genome Diagnostics, The Hague, the Netherlands
- Jean-Michel Cayuela
- Laboratoire d’hématologie, Hôpital Saint-Louis, Paris, France;Saint Louis Institute Paris Diderot, France
- Lucy Chilton
- Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
- Maarten Fornerod
- Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands;Department of Biochemistry Medical Genetics Cluster, Erasmus University Medical Center, Rotterdam, the Netherlands
- Valérie de Haas
- Dutch Childhood Oncology Group, The Hague, the Netherlands
- Christine J. Harrison
- Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
- Hiroto Inaba
- Department of Oncology and Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA
- Gertjan J.L. Kaspers
- Dutch Childhood Oncology Group, The Hague, the Netherlands;Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, the Netherlands
- Der-Cherng Liang
- Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
- Franco Locatelli
- Department of Pediatric Hematology and Oncology, IRCCS, Ospedale Bambino Gesù, Rome, and University of Pavia, Italy
- Riccardo Masetti
- Oncologia ed Ematologia Pediatrica, Ospedale Sant’Orsola Malpighi, Università di Bologna, Italy
- Christine Perot
- Unité de Cytogénétique Onco-hématologique, Hôpital Saint-Antoine, Paris, France
- Susana C. Raimondi
- Department of Oncology and Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA
- Katarina Reinhardt
- Pediatric Hematology/Oncology, AML-BFM Group, Germany
- Daisuke Tomizawa
- Department of Pediatrics, Tokyo Medical and Dental University, Japan
- Nils von Neuhoff
- Institute of Cell and Molecular Pathology, Hannover Medical School, Germany
- Marco Zecca
- Pediatric Hematology/Oncology, Fondazione IRCCS Policlinico “San Matteo”, Pavia, Italy
- C. Michel Zwaan
- Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands
- Marry M. van den Heuvel-Eibrink
- Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands
- Henrik Hasle
- Department of Pediatrics, Aarhus University Hospital Skejby, Denmark
- DOI
- https://doi.org/10.3324/haematol.2013.098517
- Journal volume & issue
-
Vol. 99,
no. 5
Abstract
Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6;9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6;9)/DEK-NUP214-rearranged myeloid leukemia; 54 diagnosed as having acute myeloid leukemia, representing
