Nature Communications (Jul 2017)
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
- Carolina Medina-Gomez,
- John P. Kemp,
- Niki L. Dimou,
- Eskil Kreiner,
- Alessandra Chesi,
- Babette S. Zemel,
- Klaus Bønnelykke,
- Cindy G. Boer,
- Tarunveer S. Ahluwalia,
- Hans Bisgaard,
- Evangelos Evangelou,
- Denise H. M. Heppe,
- Lynda F. Bonewald,
- Jeffrey P. Gorski,
- Mohsen Ghanbari,
- Serkalem Demissie,
- Gustavo Duque,
- Matthew T. Maurano,
- Douglas P. Kiel,
- Yi-Hsiang Hsu,
- Bram C.J. van der Eerden,
- Cheryl Ackert-Bicknell,
- Sjur Reppe,
- Kaare M. Gautvik,
- Truls Raastad,
- David Karasik,
- Jeroen van de Peppel,
- Vincent W. V. Jaddoe,
- André G. Uitterlinden,
- Jonathan H. Tobias,
- Struan F.A. Grant,
- Pantelis G. Bagos,
- David M. Evans,
- Fernando Rivadeneira
Affiliations
- Carolina Medina-Gomez
- Department of Internal Medicine, Erasmus MC University
- John P. Kemp
- University of Queensland Diamantina Institute, Translational Research Institute
- Niki L. Dimou
- Department of Computer Science and Biomedical Informatics of the University of Thessaly
- Eskil Kreiner
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Alessandra Chesi
- Division of Human Genetics, Children’s Hospital of Philadelphia
- Babette S. Zemel
- Division of GI, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Klaus Bønnelykke
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Cindy G. Boer
- Department of Internal Medicine, Erasmus MC University
- Tarunveer S. Ahluwalia
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Hans Bisgaard
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Evangelos Evangelou
- Department of Hygiene and Epidemiology, University of Ioannina Medical School
- Denise H. M. Heppe
- The Generation R Study Group, Erasmus Medical Center
- Lynda F. Bonewald
- Departments of Anatomy and Cell Biology and Orthopaedic Surgery, School of Medicine, Indiana University
- Jeffrey P. Gorski
- Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus Medical Center
- Serkalem Demissie
- Department of Biostatistics, Boston University School of Public Health
- Gustavo Duque
- Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health
- Matthew T. Maurano
- Institute for Systems Genetics, New York University Langone Medical Center
- Douglas P. Kiel
- Hebrew SeniorLife, Institute for Aging Research
- Yi-Hsiang Hsu
- Hebrew SeniorLife, Institute for Aging Research
- Bram C.J. van der Eerden
- Department of Internal Medicine, Erasmus MC University
- Cheryl Ackert-Bicknell
- Center for Musculoskeletal Research, University of Rochester
- Sjur Reppe
- Department of Medical Biochemistry, Oslo University Hospital
- Kaare M. Gautvik
- Unger-Vetlesen Institute, Oslo Diakonale Hospital
- Truls Raastad
- Department of Physical Performance, Norwegian School of Sports Sciences
- David Karasik
- Hebrew SeniorLife, Institute for Aging Research
- Jeroen van de Peppel
- Department of Internal Medicine, Erasmus MC University
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus Medical Center
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus MC University
- Jonathan H. Tobias
- School of Clinical Sciences, University of Bristol
- Struan F.A. Grant
- Division of Human Genetics, Children’s Hospital of Philadelphia
- Pantelis G. Bagos
- Department of Computer Science and Biomedical Informatics of the University of Thessaly
- David M. Evans
- University of Queensland Diamantina Institute, Translational Research Institute
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus MC University
- DOI
- https://doi.org/10.1038/s41467-017-00108-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.
