Human seizures couple across spatial scales through travelling wave dynamics

L-E Martinet; G. Fiddyment; J. R. Madsen; E. N. Eskandar; W. Truccolo; U. T. Eden; S. S. Cash; M. A. Kramer

doi:10.1038/ncomms14896

Nature Communications (Apr 2017)

Human seizures couple across spatial scales through travelling wave dynamics

L-E Martinet,
G. Fiddyment,
J. R. Madsen,
E. N. Eskandar,
W. Truccolo,
U. T. Eden,
S. S. Cash,
M. A. Kramer

Affiliations

L-E Martinet: Department of Neurology, Massachusetts General Hospital
G. Fiddyment: Graduate Program in Neuroscience, Boston University
J. R. Madsen: Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School
E. N. Eskandar: Department of Neurosurgery and Nayef Al-Rodhan Laboratories for Cellular Neurosurgery and Neurosurgical Technology, Massachusetts General Hospital
W. Truccolo: Department of Neuroscience & Institute for Brain Science, Brown University
U. T. Eden: Department of Mathematics and Statistics, Boston University
S. S. Cash: Department of Neurology, Massachusetts General Hospital
M. A. Kramer: Department of Mathematics and Statistics, Boston University

DOI: https://doi.org/10.1038/ncomms14896
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The authors record both local and long-range neural activity during human epileptic seizures to study the underlying multi-scale dynamics. They find that coupling of activity across spatial scales increases during seizures through propagating waves that are fit by a model that combines neural activity and potassium concentration dynamics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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