Nature Communications (Nov 2018)

Structural basis of RIP2 activation and signaling

  • Qin Gong,
  • Ziqi Long,
  • Franklin L. Zhong,
  • Daniel Eng Thiam Teo,
  • Yibo Jin,
  • Zhan Yin,
  • Zhao Zhi Boo,
  • Yaming Zhang,
  • Jiawen Zhang,
  • Renliang Yang,
  • Shashi Bhushan,
  • Bruno Reversade,
  • Zongli Li,
  • Bin Wu

DOI
https://doi.org/10.1038/s41467-018-07447-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors present the cryo-EM structure of the active RIP2-CARD filament and discuss implications for NOD1/2-RIP2 signalling.