DNA Methylation in Stroke. Update of Latest Advances

Jerzy Krupinski; Caty Carrera; Elena Muiño; Nuria Torres; Raid Al-Baradie; Natalia Cullell; Israel Fernandez-Cadenas

Computational and Structural Biotechnology Journal (Jan 2018)

DNA Methylation in Stroke. Update of Latest Advances

Jerzy Krupinski,
Caty Carrera,
Elena Muiño,
Nuria Torres,
Raid Al-Baradie,
Natalia Cullell,
Israel Fernandez-Cadenas

Affiliations

Jerzy Krupinski: Neurology Service, Hospital Universitari Mútua Terrassa, Terrasa, Barcelona, Spain; School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom
Caty Carrera: Neurovascular Research Laboratory, Institut de Recerca, Universitat Autònoma de Barcelona, Hospital Vall d'Hebron, Barcelona, Spain
Elena Muiño: Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain
Nuria Torres: Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain
Raid Al-Baradie: Applied Medical Sciences College Majmaah University, Majmaah, Saudi Arabia
Natalia Cullell: Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain
Israel Fernandez-Cadenas: Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain; Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Corresponding author at: Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, C/ Sant Antoni 19, 08221 Terrassa, Barcelona, Spain.

Journal volume & issue: Vol. 16
pp. 1 – 5

Abstract

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Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. In addition, epigenetic modifications could play an important role in cardiovascular diseases, including stroke. We review the latest advances in stroke epigenetics, focusing on DNA methylation studies and the future perspectives in this field. Keywords: Stroke, Epigenetics, Genetics, EWAs, GWAs

Published in Computational and Structural Biotechnology Journal

ISSN: 2001-0370 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.journals.elsevier.com/computational-and-structural-biotechnology-journal

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