NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

Peipei Luan; Weixia Jian; Xu Xu; Wenxin Kou; Qing Yu; Handan Hu; Dali Li; Wei Wang; Mark W. Feinberg; Jianhui Zhuang; Yawei Xu; Wenhui Peng

doi:10.1038/s41467-019-10784-y

Nature Communications (Jun 2019)

NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

Peipei Luan,
Weixia Jian,
Xu Xu,
Wenxin Kou,
Qing Yu,
Handan Hu,
Dali Li,
Wei Wang,
Mark W. Feinberg,
Jianhui Zhuang,
Yawei Xu,
Wenhui Peng

Affiliations

Peipei Luan: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Weixia Jian: Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine
Xu Xu: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Wenxin Kou: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Qing Yu: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Handan Hu: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
Dali Li: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
Wei Wang: Columbia Center for Translational Immunology, Columbia University Medical Center
Mark W. Feinberg: Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Jianhui Zhuang: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Yawei Xu: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Wenhui Peng: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University

DOI: https://doi.org/10.1038/s41467-019-10784-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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